Table 1 Modulation of mitophagy in breast cancer-currently available pharmaceutical agents.
Agents | Cell lines | Pathways | Effects | Years |
|---|---|---|---|---|
Liensinine [146] | MDA-MB-231 | Inhibit autophagosomal-lysosomal fusion | Inhibit mitophagy | 2015 |
Olaparib [151] | BRCA mutant cells | Unknown | Induce mitophagy | 2015 |
Polyphyllin I [125] | MDA-MB-231, MCF-7 | PINK1-mediated | Induce mitophagy | 2017 |
Flavonoid TL-2-8 [156] | MDA-MB-231, MDA-MB-468 | PINK1-mediated | Induce mitophagy | 2017 |
Chalcomoracin [157] | MDA-MB-231 | PINK1-mediated | Induce mitophagy | 2018 |
Vincristine [77] | MDA-MB-231 | Hsp70 acetylation | Induce mitophagy | 2019 |
B5G1 [158] | MCF-7/ADR | PINK1-mediated | Induce mitophagy | 2019 |
Silibinin [124] | MDA-MB-231, MCF-7 | PINK1-mediated | Induce mitophagy | 2020 |
Ginsenoside Rh2 [159] | Senescent MCF-10A | PINK1-mediated | Induce mitophagy | 2020 |
MDA-MB-231, BT-549, T-47D | Upregulate BNIP3, BNIP3L, and PINK1 | Induce mitophagy | 2020, 2023 | |
Metformin Prodrugs [160] | MDA-MB-231 | Unknown | Induce mitophagy | 2021 |
Warangalone [126] | MDA-MB-231, MCF-7 | PINK1-mediated | Induce mitophagy | 2021 |
Flubendazole [74] | MDA-MB-231, MCF-7 | PINK1-mediated | Induce mitophagy | 2022 |
Taloxifene [161] | MCF-7 | PINK1-mediated | Induce mitophagy | 2022 |
Guangsangon E [155] | MDA-MB-231, MDA-MB-468, MDA-MB-453 | PINK1-mediated | Induce mitophagy | 2022 |
Gramicidin A [162] | MCF-7 | Unknown | Induce mitophagy | 2022 |
Cepharanthine [163] | MDA-MB-231 | PINK1-mediated | Inhibit mitophagy | 2022 |
Artesunate [164] | MDA-MB-231 | PINK1-mediated | Induce mitophagy | 2022 |
Acid ground nano-realgar processed product [76] | MDA-MB-435S | PINK1-mediated | Induce mitophagy | 2023 |
Kaempferol [75] | MCF-10AT | PINK1-mediated | Induce mitophagy | 2023 |
Costunolide [165] | MCF-7 | PINK1-mediated | Induce mitophagy | 2023 |
Copper complex CPT8 [166] | MDA-MB-231 | PINK1 and BNIP3-mediated | Induce mitophagy | 2023 |
Baicalein [167] | MDA-MB-231 | PINK1-mediated | Induce mitophagy | 2023 |
Ru-TPE-PPh complex [168] | MDA-MB-231 | PINK1-mediated | Induce mitophagy | 2024 |
Idebenone [169] | MDA-MB-231, MDA-MB-468 | Unknown | Induce mitophagy | 2024 |
