Fig. 3: Selective deletion of MIAT in cardiomyocytes reduces damage and the expression of proinflammatory Il-1b in the heart after chronic myocardial infarction. | Cell Death Discovery

Fig. 3: Selective deletion of MIAT in cardiomyocytes reduces damage and the expression of proinflammatory Il-1b in the heart after chronic myocardial infarction.

From: Cardiomyocyte-restricted MIAT deletion is sufficient to protect against murine myocardial infarction

Fig. 3

A Representative hematoxylin and eosin (H&E) staining of heart sections of the peri-ischemic border area at 4 weeks post-MI shows a decrease in disorganized structure in CM-specific MIAT cKO hearts compared to MIATfl/fl controls. Scale bars: 100ÎŒm. B–D QRT-PCR analysis of Nppa, Nppb, and Myh7 expression representing cardiac damage in ischemic areas from CM-specific MIAT cKO hearts compared to MIATfl/fl controls at 4 weeks post-MI. E QRT-PCR analysis of Il-1b expression for cardiac inflammation in ischemic areas from CM-specific MIAT cKO hearts compared to MIATfl/fl controls at 4 weeks post-MI. N = 3 per group. QRT-PCR data are shown as fold induction of gene expression normalized to Gapdh. Data are presented as mean ± SEM. Two-way ANOVA with Tukey’s multiple comparison test. *P < 0.05, **P < 0.01, or ***P < 0.001 vs. sham of same genotype; #P < 0.05 or ##P < 0.01 vs. MI MIATfl/fl.

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