Fig. 4: Cardiomyocyte-specific MIAT loss in mice alleviates cardiac apoptosis following chronic myocardial infarction. | Cell Death Discovery

Fig. 4: Cardiomyocyte-specific MIAT loss in mice alleviates cardiac apoptosis following chronic myocardial infarction.

From: Cardiomyocyte-restricted MIAT deletion is sufficient to protect against murine myocardial infarction

Fig. 4

A–B Representative cleaved-caspase 3 staining images in heart sections of the peri-ischemic border area at 4 weeks post-MI (A) and quantification of apoptosis in six 20x fields (B). Scale bars: 50ÎŒm. C–D, QRT-PCR analysis of proapoptotic p53 and Bak1 expression in the ischemic areas from CM-specific MIAT cKO hearts compared to MIATfl/fl controls at post-MI 4 weeks. QRT-PCR data are shown as fold induction of gene expression normalized to Gapdh. N = 3–7 per group. Data are presented as mean ± SEM. Two-way ANOVA with Tukey’s multiple comparison test. *P < 0.05, **P < 0.01, or ***P < 0.001 vs. sham of same genotype; #P < 0.05, ##P < 0.01, or ###P < 0.001 vs. MI MIATfl/fl.

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