Fig. 6: Selective knockdown of MIAT in cardiomyocytes decreases the cardiac expression of profibrotic genes post-myocardial infarction.
From: Cardiomyocyte-restricted MIAT deletion is sufficient to protect against murine myocardial infarction
QRT-PCR analysis of profibrotic Col3a1 (A), Col6a1 (B), Postn (C), or Snail1 (D) expression in ischemic areas from MIATfl/fl and CM-specific MIAT cKO mouse left ventricles at 4 weeks post-MI. Data are shown as the fold induction of gene expression normalized to Gapdh. N = 3 per group. Data are presented as the mean ± SEM. Two-way ANOVA with Tukey’s multiple comparison test. *P < 0.05, **P < 0.01, or ***P < 0.001 vs. sham of same genotype; #P < 0.05 or ##P < 0.01 vs. MI MIATfl/fl.
