Fig. 3: The gut microbiota modulates HCC progression via metabolites. | Cell Death Discovery

Fig. 3: The gut microbiota modulates HCC progression via metabolites.

From: Roles of the gut microbiota in hepatocellular carcinoma: from the gut dysbiosis to the intratumoral microbiota

Fig. 3

SCFAs (butyrate, propionate, acetate) downregulate PI3K/NF-κB signaling in HBV-HCC. L. reuteri-derived acetate suppresses IL-17A in ILC3s, exerting anti-tumor effects. Bifidobacterium pseudolongum-derived acetate binds GPR43, inhibiting IL-6/JAK1/STAT3 in NAFLD-HCC. Butyrate synergizes with berberine to stabilize PPARδ, enhancing apoptosis via caspase 3/BAX.

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