Table 2 The most commonly used inhibitors of DRP1.

From: DRP1, fission and apoptosis

Inhibitors

Mechanisms

DRP1i27

Binding to the human isoform 3 of Drp1 and inhibiting the activity of GTPase [143].

P110

Inhibiting Drp1 enzyme activity and blocking Drp1-Fis1 interaction [144].

Mdivi-1

Attenuating the polymerization of DRP1 to higher order structures at early stages of fission by inhibiting GTPase activity [103, 145].

Anti-inflammatory agent 49

Inhibiting the GTPase activity of Drp1 and Drp1-Fis1 interaction [146].

Drpitor1a

Suppressing the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1 [147].

MB0223

Selectively inhibiting the oligomeric form of DRP1 [148].

Honokiol DCA

Blocking the phosphorylation of DRP1 at Ser-616 [149].

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