Fig. 1: Depiction of the three primary autophagic mechanisms. | Cell Death Discovery

Fig. 1: Depiction of the three primary autophagic mechanisms.

From: Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance

Fig. 1

Macroautophagy entails the generation of a phagophore that envelops the cargo, culminating in the formation of an autophagosome. This entity subsequently merges with a lysosome to create an autolysosome where degradation transpires. Microautophagy is portrayed by the direct engulfment of the substrate via the invagination of lysosomal or late endosomal membranes. Chaperone-mediated autophagy involves the recognition by the lysosome-associated receptor LAMP2A of specific cytosolic proteins harboring a KFERQ-like motif. The chaperone heat shock cognate protein 70 (Hsc70) aids in the translocation of these proteins into the lysosome for degradation.

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