Fig. 1: Molecular mechanisms of m6A writers, erasers, and readers in prostate cancer.
From: Emerging implications of N6-methyladenosine in prostate cancer progression and treatment
The m6A Reader protein YTHDF2 promotes prostate cell proliferation by modulating the phosphorylation of downstream AKT signaling. YTHDF1 enhances anti-tumor immunity in prostate cancer by regulating mRNA stability and thereby affecting protein expression in T cells. The Eraser proteins FTO and ALKBH5 modulate the m6A methylation level of TSPAN1, leading to the suppression of autophagy in prostate cancer cells. The Writer protein METTL14 increases m6A abundance, thereby promoting T cell infiltration into the tumor microenvironment. In contrast, downregulation of METTL3 has been shown to inhibit prostate cancer progression.
