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References
Jeyanathan, M. et al. Nat. Rev. Immunol. 20, 615–632 (2020).
Sadoff, J. et al. N. Engl. J. Med. 384, 1824–1835 (2021).
Xia, S. et al. Lancet Infect. Dis. 21, 39–51 (2021).
Xia, S. et al. JAMA 324, 951–960 (2020).
Scheiermann, C. Nat. Rev. Immunol. 18, 423–437 (2018).
Long, J. E. Vaccine 34, 2679–2685 (2016).
de Bree, L. C. J. et al. J. Clin. Invest. 130, 5603–5617 (2020).
Woodruff, M. C. et al. Nat. Immunol. 21, 1506–1516 (2020).
Dan, J. M. et al. Science 371, eabf4063 (2021).
Druzd, D. et al. Immunity 46, 120–132 (2017).
Acknowledgements
We thank Drs. Ji Wang and Liping Wu for blood sample collection and technical support. This work was supported by The Talent Program of First Affiliated Hospital, Sun Yat-sen University (Y70311). H.Z. was supported by The Hundred Talent Program of Sun Yat-sen University (Y61229).
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H.X. and S.P. supervised the study. H.X., S.P., H.Z. and Y.L. conceived and designed the study. Y.L., Q.Zeng, L.L., M.L. and J.M. collected and processed blood samples. Q.Zeng, M.L. and L.L. performed the experiments and collected data. Q.Zeng and Q.Zhou performed statistical analysis. H.Z., Y.L., D.L., Q.Zeng, L.L. and M.L. drafted the report. H.X., S.P., N.Y., S.M., Q.L. and M.L. made critical revision on the manuscript. All authors contributed to the interpretation of data, and revised the manuscript and approved the final version before submission.
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Zhang, H., Liu, Y., Liu, D. et al. Time of day influences immune response to an inactivated vaccine against SARS-CoV-2. Cell Res 31, 1215–1217 (2021). https://doi.org/10.1038/s41422-021-00541-6
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DOI: https://doi.org/10.1038/s41422-021-00541-6
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