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Data availability
Structure coordinate has been deposited in the Protein Data Bank under accession code 7WP5 (Omicron-S6P:VacW-209). The corresponding density maps have been deposited in the Electron Microscopy Data Bank under accession numbers EMD-32674 (Omicron-S6P:VacW-209) and EMD-32669 (Omicron-S6P:VacW-209, local refinement).
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Acknowledgements
This study was supported by the National Science Fund for Distinguished Young Scholars (82025022), the National Natural Science Foundation of China (92169204, 82002140, 82171752, 82101861, 81991491), the National Key Plan for Scientific R&D of China (2021YFC0864500), the Guangdong Basic and Applied Basic Research Foundation (2021B1515020034, 2021B1212030010, 2019A1515011197, 2021A1515011009, 2020A1515110656), the Shenzhen Science and Technology Program (RCYX20200714114700046), and the Science and Technology Innovation Committee of Shenzhen Municipality (JSGG20200207155251653, JSGG20200807171401008, KQTD20200909113758004, JCYJ20190809115617365, JSGG20210901145200002).
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Z.Z., N.X., S.L., and B.J. conceived and designed the study. B.J., Q.Z., H.G., Q.F., T.L., S. Song, and H.S. performed all experiments and analyzed data together with S. Shen, X.Z., W.X., L.C., and B.Z. Z.Z., N.X., S.L., B.J., and Q.Z. participated in discussion of the results and wrote the paper. All authors read and approved this version of paper.
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Ju, B., Zheng, Q., Guo, H. et al. Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209. Cell Res 32, 491–494 (2022). https://doi.org/10.1038/s41422-022-00638-6
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DOI: https://doi.org/10.1038/s41422-022-00638-6
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