Fig. 5: Recent evidence supporting alternative models of histological transformation.
From: Lineage plasticity and histological transformation: tumor histology as a spectrum
Models of transformation during selective pressure-driven tumor evolution (arrows), such as targeted anti-tumor therapy. Two models are depicted, histological transformation through a dedifferentiated intermediate stem-like state (top) or through a squamous-like intermediate state (bottom). Cell type legend can be found at the bottom of the figure. Question marks account for yet undescribed additional molecular alterations potentially driving transition among different cell states. Figure generated with BioRender.com.
