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CD137 ligand interacts with CD32a to trigger reverse CD137 ligand signaling

Cellular & Molecular Immunology volume 17, pages 1188–1189 (2020)Cite this article

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CD32a contributes to inflammation by interacting with CD137L to induce inflammatory dendritic cell differentiation.

CD137 ligand (CD137L) is a costimulatory ligand that is expressed on antigen-presenting cells (APCs) and is important for enhancing T cell activation by crosslinking CD137 on activated T cells.1,2,3 While CD137 triggers a costimulatory signal in T cells, CD137L has been reported to trigger reverse signaling in APCs.4 In human monocytes, reverse CD137L signaling leads to the differentiation of dendritic cells (DCs), which are termed CD137L-DCs.5 CD137L-DCs are a novel type of DC and a potent candidate for DC-based cancer immunotherapy. CD137L-DCs are effective at polarizing Th1 and Tc1 responses and induce stronger cytotoxic T cell responses than those of monocyte-derived DCs generated with the more commonly used granulocyte–macrophage colony-stimulating factor and interleukin-4 (IL-4).5,6,7

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Acknowledgements

This research was supported by a grant (NMRC/BnB/018b/2015) from the National Medical Research Council of Singapore. We thank the LSI core facility, Dr. Paul MacAry for the donation of WT and LALA-mutated antibodies, and the YLLSOM Confocal Microscopy Unit.

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Authors and Affiliations

  1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Qun Zeng, Ye Mon Soe & Herbert Schwarz

  2. Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore

    Qun Zeng, Ye Mon Soe & Herbert Schwarz

  3. Functional Proteomics Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore

    Yanting Lim & Radoslaw M. Sobota

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  1. Qun Zeng
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  2. Ye Mon Soe
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  5. Herbert Schwarz
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Correspondence to Herbert Schwarz.

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Zeng, Q., Soe, Y.M., Lim, Y. et al. CD137 ligand interacts with CD32a to trigger reverse CD137 ligand signaling. Cell Mol Immunol 17, 1188–1189 (2020). https://doi.org/10.1038/s41423-020-0370-6

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