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MicroRNA-99a: a potential double-edged sword targeting macrophage inflammation and metabolism

Cellular & Molecular Immunology volume 18, pages 2290–2292 (2021)Cite this article

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In a recent study published in Cellular and Molecular Immunology, Jaiswal et al. demonstrated the importance of microRNA-99a (miR-99a) in adipose tissue inflammation and macrophage phenotype activation [1]. In this study, miR-99a mimics inhibited the M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα, which was accompanied by an improvement in diabetic dyslipidemia and insulin signaling [2]. This study highlights the therapeutic importance of miR-99a in metabolic diseases in which inflammation is a key player.

Targeting inflammation and the adipose tissue microenvironment is an ongoing strategy in understanding and designing therapeutic strategies for lifestyle- or obesity-dependent diabetes [3, 4]. Although reports suggest that local insulin resistance occurs before inflammation and vice versa [5, 6], based on several findings, there is a consensus that insulin resistance can be reversed by limiting inflammation. Some of the anti-inflammatory interventions that have gone to clinical trials include IKKε, TBK1 inhibitors, GPR-120 agonists, CCR-2 antagonists, LTB4R1 inhibitors, TNF inhibitors (etanercept, infliximab) and CRP, TNF, and IL‑6 suppressors (salicylate and aspirin) [4].

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Authors and Affiliations

  1. Department of Pharmacology, Counsil of Scientific and Industrial Research-Central Drug Research Institution, Lucknow, India

    Mohita Maurya & Manoj Kumar Barthwal

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

    Manoj Kumar Barthwal

Authors
  1. Mohita Maurya
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  2. Manoj Kumar Barthwal
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Contributions

MM prepared graphical abstract. MKB wrote and finalized the manuscript and graphical abstract. This manuscript has CSIR-CDRI communication no 10264.

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Correspondence to Manoj Kumar Barthwal.

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The authors declare no competing interests.

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Maurya, M., Barthwal, M.K. MicroRNA-99a: a potential double-edged sword targeting macrophage inflammation and metabolism. Cell Mol Immunol 18, 2290–2292 (2021). https://doi.org/10.1038/s41423-021-00745-1

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