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Gasdermin D unlocks metabolic pathways to enhance tissue regeneration

Cellular & Molecular Immunology volume 22, pages 1–3 (2025)Cite this article

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Gasdermin D (GSDMD) is traditionally associated with the inflammatory response to pyroptosis but plays a significant role in tissue repair. One study demonstrated the involvement of GSDMD in the secretion of the pro-regenerative metabolite 11,12-epoxyeicosatrienoic acid (11,12-EET), which significantly enhances muscle regeneration, opening new therapeutic avenues for treating degenerative diseases [1].

Inflammation and tissue repair are fundamental processes that influence both physiological adaptations and pathological outcomes. These processes often hinge on complex interactions between immune cells and tissue-resident cells, collectively orchestrating effective tissue regeneration following injury. GSDMD, which is known primarily for its role in pyroptosis—a form of programmed cell death that promotes inflammation [2, 3]—is now acknowledged for its broader capabilities. Recent research by Wang and coworkers published in Nature highlights a novel aspect of GSDMD functionality: its potential to facilitate tissue repair through the mediation of metabolic crosstalk [1].

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  1. Institute of Chemistry, University of Silesia in Katowice, Katowice, Poland

    Quazi T. H. Shubhra

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  1. Quazi T. H. Shubhra
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Correspondence to Quazi T. H. Shubhra.

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Shubhra, Q.T.H. Gasdermin D unlocks metabolic pathways to enhance tissue regeneration. Cell Mol Immunol 22, 1–3 (2025). https://doi.org/10.1038/s41423-024-01239-6

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