Abstract
Three new polyketides, (2S)-2,3-dihydro-5,6-dihydroxy-2-methyl-4H-1-benzopyran-4-one (1), (2′R)-2-(2′-hydroxypropyl)-4-methoxyl-1,3-benzenediol (2), and 4-ethyl-3-hydroxy-6-propenyl-2H-pyran-2-one (3) were isolated from the culture broth of Colletotrichum gloeosporioides, an endophytic fungus derived from the mangrove Ceriops tagal. The structures of 1–3 were elucidated on the basis of NMR spectra and HR-ESI-MS data. Their absolute configurations were determined by comparing with the experimental and calculated ECD spectrum. Compounds 1 and 3 showed potent antibacterial activities against some of the tested microbes.
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Acknowledgements
This work was supported by the Foundation for the National Natural Science Foundation of China (No. 21662012) and Program for Innovative Research Team in University (No. IRT-16R19).
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Luo, YP., Zheng, CJ., Chen, GY. et al. Three new polyketides from a mangrove-derived fungus Colletotrichum gloeosporioides. J Antibiot 72, 513–517 (2019). https://doi.org/10.1038/s41429-019-0178-8
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DOI: https://doi.org/10.1038/s41429-019-0178-8
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