Fig. 4: Significant metabolites that changed with the portfolio diet intervention from baseline in study two. | European Journal of Clinical Nutrition

Fig. 4: Significant metabolites that changed with the portfolio diet intervention from baseline in study two.

From: Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials

Fig. 4

a Metabolite classes of the 63 metabolites significantly changed after the portfolio diet intervention from a total of 496 metabolites assessed. b Volcano plot of mean difference in plasma metabolites over 4 weeks after consumption of the portfolio diet from baseline. Significant metabolites were estimated from 25 participants via linear mixed models and included a Bonferroni adjustment for multiple testing (p < 0.0001). The models (per 1-SD increment in each metabolite) incorporated participant-specific intercepts as a random effect and the fixed effects were diet, time (week), and the interaction between time and diet (diet x week). See Supplemental Table 6 for full list of significant metabolites.

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