Table 3 Metabolites that significantly differed within both portfolio diet intervention studies from baseline (n = 52).

From: Metabolomic profiling of a cholesterol lowering plant-based diet from two randomized controlled feeding trials

Class	Subclass	Metabolite	Rep¹	HMDB ID	Direction²
Amino acids and peptides	Amino acids	1-Methylhistidine	1	HMDB0000001	↓
	Amino acids	O-Ethylhomoserine	NA	NA	↑
Carnitines	Acyl carnitines	Arachidyl carnitine	1	HMDB0006460	↓
	Acyl carnitines	Hexacosanoyl carnitine	1	HMDB0006347	↓
	Acyl carnitines	Stearoylcarnitine	1	HMDB0000848	↓
Glycerophosphocholines	O-PC	PC(16:0/22:6)	2	HMDB0011229	↓
	O-LPC	LysoPC(O-18:0/0:0)	1	HMDB0011149	↓
	O-PC	PC P-35:1 or PC O-35:2	NA	NA	↓
	O-PC	PC(14:0/P-18:0)	2	HMDB0007896	↓
	PC	PC(16:0/18:0)	2	HMDB0007970	↓
	PC	PC(18:0/18:0)	2	HMDB0008036	↓
	PC	PC(18:0/18:1)	2	HMDB0008038	↓
	O-PC	PC(18:0/P-18:0)	2	HMDB0008061	↓
	O-PC	PC(18:4/P-18:1)	2	HMDB0008260	↓
	PC	PC(20:5/20:5)	2	HMDB0008511	↓
	PC	PC(22:6/18:3)	2	HMDB0008731	↓
	PC	PC(38:6)	2	HMDB0007991	↓
	PC	PC(40:6)	2	HMDB0008057	↓
	O-PC	PC(P-16:0/18:1)	2	HMDB0011210	↓
	O-PC	PC(P-16:0/18:3)	2	HMDB0011212	↓
	O-PC	PC(P-16:0/20:4)	2	HMDB0011221	↓
	O-PC	PC(P-18:0/18:1)	2	HMDB0011243	↓
	O-PC	PC(P-18:0/18:2)	2	HMDB0011244	↓
	O-PC	PC(P-18:0/20:3)	2	HMDB0011252	↓
	O-PC	PC(P-18:1/14:0)	2	HMDB0011269	↓
	O-PC	PC(P-18:1/18:2)	2	HMDB0011310	↓
	O-PC	PC(P-18:1/20:4)	2	HMDB0011319	↓
	O-PC	PC(P-18:1/22:5)	2	HMDB0011294	↓
	O-PC	PC(P-18:1/18:2)	2	HMDB0011310	↓
	PE	PE(15:0/22:4)	2	HMDB0008910	↑
	PE	PE(18:0/20:4)	2	HMDB0009003	↑
Glycerophosphoethanolamines	PE	PE P-39:6 or PE O-39:7	NA	NA	↓
	O-PE	PE P-42:10 or PE O-42:11	NA	NA	↓
	O-PE	PE(18:0/P-18:0)	2	HMDB0009016	↓
	O-PE	PE(18:1/P-18:0)	2	HMDB0009082	↓
	O-PE	PE(P-18:0/20:3)	2	HMDB0011384	↓
	O-PE	PE(P-18:0/20:4)	2	HMDB0005779	↓
	O-PE	PE(P-18:0/20:5)	2	HMDB0011387	↓
	O-PE	PE(P-18:0/22:6)	2	HMDB0011394	↓
	O-PE	PE(P-18:1/20:5)	2	HMDB0011420	↓
	O-LPE	LysoPE(P-18:0/0:0)	2	HMDB0240598	↓
Glycosphingolipids	HexCer	GlcCer 18:2;O2/22:0	NA	NA	↓
Imidazoles	Imidazolyl carboxylic acids	Methylimidazoleacetic acid	1	HMDB0002820	↓
Sphingomyelins	SM	SM(d18:1/22:0)	1	HMDB0012103	↓
	SM	SM(d18:1/22:1)	2	HMDB0012104	↓
	SM	SM(d18:1/24:0)	1	HMDB0011697	↓
Sterol esters	Chol. esters	CE(16:0)	1	HMDB0000885	↓
	Chol. esters	CE(16:1)	2	HMDB0000658	↓
	Chol. esters	CE(18:0)	1	HMDB0010368	↓
	Chol. esters	CE(20:5)	1	HMDB0006731	↓
Sterols	Ergosterols	Campesterol	1	HMDB0002869	↓
	Cholesterols	Cholesterol	1	HMDB0000067	↓

1=match, 2=representative, NA=not available.
2=no metabolites differed in direction between the two trials.
Chol. Esters cholesteryl esters, PE phosphatidylethanolamine, PC phosphatidylcholine, HexCer hexosylceramide, SM sphingomyelin, O-PC plasmalogen phosphatidylcholine, O-PE plasmalogen phosphatidylethanolamine, O-LPE ether-linked lysophosphatidylethanolamine, O-LPC ether-linked lysophosphatidylcholine.

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Table 3 Metabolites that significantly differed within both portfolio diet intervention studies from baseline (n = 52).

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