Fig. 2: Wsb2-mutant mice exhibited with lower body weight and retinal abnormalities in both males and females. | European Journal of Human Genetics

Fig. 2: Wsb2-mutant mice exhibited with lower body weight and retinal abnormalities in both males and females.

From: Recessive variants in WSB2 encoding a substrate receptor of E3 ubiquitin ligase underlie a neurodevelopmental syndrome

Fig. 2

A Shows the body weight at different ages (4–15 week) between control and Wsb2-mut mice. n = 7–8 mice per group and per genotype, median and interquartile range shown. B–E Show the retinal abnormalities in Wsb2-mut mice, including irregular retinal blood vessel morphology (B, D) and reduced total retinal thickness (C, E) as shown in the left eye. For control group: n = 15, 8 females and 7 males; and for Wsb2-mut mice: n = 11, 6 females and 5 males. The right eye showed a similar phenotype. Red boxes in (C) represent an arbitrary evaluation of total retinal thickness, using equally sized rectangles over the retinal layers in control and Wsb2-mut mice to illustrate the reduction in thickness across all retinal layers.

Back to article page