Table 2 Anxiety, decision regret and reproductive confidence at 12 months post-result.

	Result^a
	Low	New increased chance	Known increased chance
N	4797	116	71
State anxiety^b at enrolment (median, IQR)	30 (23.3–36.7)	30 (23.3–40.0)	33.3 (26.7–43.3)
State anxiety at 12 months post-result (median, IQR)	26.6 (20–36.7)	38.3 (26.7–50.0)	40 (33.3–50.0)
Change in state anxiety (mean, 95% CI)	−2.2 (−2.5–−1.8)	6.8 (4.2–9.5)	5.0 (1.6–8.4)
State anxiety ≥40 at enrolment (N, %)	1139 (23.7)	36 (31)	27 (38)
State anxiety ≥40 at 12 months post-result (N, %)	1042 (21.3)	58 (50.0)	42 (59.2)
Decision regret^c (median, IQR)	0 (0–10)	5 (0–15)	0 (0–10)
Reproductive confidence (N, %)
No confidence	16 (0.3)	1 (0.9)	4 (5.6)
Not much confidence	47 (1.00)	8 (6.9)	9 (12.7)
Some confidence	1441 (30.0)	59 (50.9)	21 (29.6)
A lot of confidence	3293 (68.6)	48 (41.4)	37 (52.1)

IQR interquartile range.
^a‘New’ increased chance refers to people newly identified through Mackenzie’s Mission as having an increased chance of having children with a condition screened. ‘Known’ increased chance refers to people who already knew they had an increased chance of children with one of conditions screened prior to taking part in Mackenzie’s Mission and received a low chance for all other conditions screened in the study.
^bAnxiety measured by the 6-item State Trait Anxiety Inventory (score range 20-80, higher scores indicate higher anxiety) [29]. Scores ≥40 indicate clinically meaningful anxiety [30].
^cDecision regret measured by the Decision Regret Scale (scores range from 0-100, higher scores indicate higher anxiety) [31].

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