Table 1 Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and kappa agreement of EyeArt for detection of any varying degrees of DR with ophthalmologist grading as reference standard

From: Automated diabetic retinopathy detection in smartphone-based fundus photography using artificial intelligence

Retinopathy

Sensitivity, % (95% CI)

Specificity, % (95% CI)

PPV

(95% CI)

NPV

(95% CI)

Kappa

(95% CI)

p-value

Any DR

95.8

(92.9, 98.7)

80.2

(72.6, 87.8)

89.7

(85.5, 93.8)

91.4

(85.7, 97.1)

0.78

(0.71, 0.86)

<0.001

DME

97

(91.5, 99.4)

75.8

(69.7, 81.8)

67.4

(59.7, 75.0)

98.0

(94.3, 99.6)

0.66

(0.58, 0.74)

<0.001

PDR

78.1

(63.8, 83.3)

89.8

(86.1, 93.4)

48.1

(34.5, 61.7)

97.1

(95.0, 99.2)

0.53

(0.4, 0.67)

<0.001

STDR

99.1

(95.1, 99.9)

80.4

(73.9, 85.9)

75.3

(68.4, 82.3)

99.3

(96.3, 100)

0.75

(0.67, 0.83)

<0.001

RDR

99.3

(96.1, 99.9)

68.8

(61.5, 76.2)

74.6

(68.4, 80.8)

99.1

(97.2, 100)

0.67

(0.59, 0.75)

<0.001

  1. Any DR diabetic retinopathy (any stage), DME diabetic macular oedema, PDR proliferative diabetic retinopathy, STDR sight-threatening diabetic retinopathy (severe NPDR, PDR and DME), RDR referable diabetic retinopathy (moderate NPDR and above and/or presence of clinically significant macular oedema [CSME])