Abstract
Purpose
To describe the vascular changes of circumscribed choroidal hemangioma (CCH) after ruthenium-106 brachytherapy using optical coherence tomography angiography (angio-OCT).
Methods
Seven eyes of 7 patients diagnosed with symptomatic CCH who underwent ruthenium-106 plaque radiotherapy were included in the study. Patients underwent complete ophthalmic examination, bulbar echography and angio-OCT. The same protocol was applied 1 year after ruthenium-106 brachytherapy.
Results
At baseline, the mean best-corrected visual acuity (BCVA) in affected eyes was 0.67 ± 0.14 logMAR, and the mean tumor thickness was 4.46 ± 0.91 mm measured by standardized A-scan echography. After ruthenium-106 plaque treatment, the mean BCVA increased to 0.17 ± 0.10 logMAR (p = 0.001) and the mean tumor thickness to 2.29 ± 0.71 mm (p = 0.003). Moreover, there was a significant reduction of the tumor basal diameter (p= 0.009). Intra-tumor angio-OCT measurements revealed a statistically significant reduction of the vessel and flow areas (p = 0.006 and p = 0.002, respectively) 1 year after brachytherapy.
Conclusions
Angio-OCT is a non-invasive reliable method with which to evaluate the vascular features of CCH and consequently to monitor changes after conservative treatment.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Madreperla SA, Hungerford JL, Plowman PN, Laganowski HC, Gregory PT. Choroidal hemangioma visual and anatomic results of treatment by photocoagulation or radiation therapy. Ophthalmology. 1997;104:1773–9.
Shields CL, Honavar SG, Shields JA, Cater J, Demirci H. Circumscribed choroidal hemangioma: clinical manifestations and factors predictive of visual outcome in 200 consecutive cases. Ophthalmology. 2001;108:2237–48.
Mashayekhi A, Shields CL. Circumscribed choroidal hemangioma. Curr Opin Ophthalmol. 2003;14:142–9.
Cennamo G, Breve MA, Rossi C, Romano MR, de Crecchio G, Cennamo G. Tranpupillary thermotherapy as a primary treatment for circumscribed choroidal haemangioma. Acta Ophthalmol. 2016;94:e167–169.
Kivelä T, Tenhunen M, Joensuu T, Tommila P, Joensuu H, Kouri M. Stereostatic radiotherapy of symptomatic circumscribed choroidal hemangiomas. Ophthalmology. 2003;110:1977–82.
Singh AD, Kaiser PK, Sears JE. Choroidal hemangioma. Ophthalmol Clin North Am. 2005;18:151–61.
López-Caballero C1, Saornil MA, De Frutos J, Bianciotto C, Muiños Y, Almaraz A, López-Lara F, Contreras I. High-dose iodine-125 episcleral brachytherapy for circumscribed choroidal hemangioma. Br J Ophthalmol. 2010;94:470–3.
Joshi S, Reddy VAR, Ganesa P, Ali MJ, Naik MN, Honavar SJ. Ruthenium 106 plaque brachytherapy: indications and outcome in ocular tumors. J Cancer Res Ther. 2009;5:S88–9.
Naseripour M, Maleki A, Astaraki A, Sedaghat A, Jaberi R, Lee S, Azma Z, Silpa-Archa S. Ruthenium-106 brachytherapy in the treatment of circumscribed choroidal hemangioma. Retina. 2018;38:1024–1030.
Spaide RF, Fujimoto JG, Waheed NK. Optical coherence tomography angiography. Retina. 2015;35:2161–2.
Shields CL, Pellegrini M, Ferenczy SR, Shields JA. Enhanced depth imaging optical coherence tomography of intraocular tumors: from placid to seasick to rock and rolling topography—the 2013 Francesco Orzalesi Lecture. Retina. 2014;34:1495–512.
Heimann H, Jmor F, Damato B. Imaging of retinal and choroidal vascular tumours. Eye (Lond). 2013;27:208–16.
Rojanaporn D, Kaliki S, Ferenczy SR, Shields CL. Enhanced depth imaging optical coherence tomography of circumscribed choroidal hemangioma in 10 consecutive cases. Middle East Afr J Ophthalmol. 2015;22:192–7.
Torres VL, Brugnoni N, Kaiser PK, Singh AD. Optical coherence tomography enhanced depth imaging of choroidal tumors. Am J Ophthalmol. 2011;151:586–93.
Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008;146:496–500.
Cennamo G, Romano MR, Breve MA, Velotti N, Reibaldi M, de Crecchio G, Cennamo G. Evaluation of choroidal tumors with optical coherence tomography: enhanced depth imaging and OCT-angiography features. Eye (Lond). 2017;31:906–15.
Takkar B, Azad S, Shakrawal J, Gaur N, Venkatesh P. Blood flow pattern in a choroidal hemangioma imaged on swept-source-optical coherence tomography angiography. Indian J Ophthalmol. 2017;65:1240–2.
Kubicka-Trząska A, Karska-Basta I, Oleksy P, Romanowska-Dixon B. Management of diffuse choroidal hemangioma in Sturge-Weber syndrome with ruthenium-106 plaque radiotherapy. Graefes Arch Clin Exp Ophthalmol. 2015;253:2015–9.
Arevalo JF, Shields CL, Shields JA, et al. Circumscribed choroidal hemangioma: characteristic features with indocyanine green videoangiography. Ophthalmology. 2000;107:344–50.
Witschel H, Font RL. Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature. Surv Ophthalmol. 1976;20:415–31.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Cennamo, G., Rossi, C., Breve, M.A. et al. Evaluation of vascular changes with optical coherence tomography angiography after ruthenium-106 brachytherapy of circumscribed choroidal hemangioma. Eye 32, 1401–1405 (2018). https://doi.org/10.1038/s41433-018-0100-9
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/s41433-018-0100-9
This article is cited by
-
Swept-source optical coherence tomography and swept-source optical coherence tomography angiography findings in circumscribed choroidal hemangioma before and after transpupillary thermotherapy
Lasers in Medical Science (2024)
-
Optical coherence tomography angiography (OCTA) applications in ocular oncology
Eye (2020)
