Table 2 Univariable analysis of the associations between the maximum cup depth (mm) and ocular and systemic parameters of the Handan eye study (40 POAG and 4194 non-glaucoma)

Parameters	P-value	Coefficient B	95% CI of B
Age (years)	<0.001	−0.003	−0.004, −0.003
AL (mm)	<0.001	0.025	0.017, 0.033
IOP (mmHg)	0.006	0.003	0.001, 0.006
TLCPD (mmHg)	0.006	−0.003	−0.004, −0.001
CSFP (mmHg)	<0.001	0.006	0.004, 0.008
DA (mm²)	<0.001	0.210	0.210, 0.236
CRAE (μm)	<0.001	−0.001	−0.001, 0.000
CRVE (μm)	0.003	−0.0003	0.000, 0.000
SBP (mmHg)	<0.001	−0.001	−0.001, −0.001
DBP (mmHg)	0.800	<0.001	0.000, 0.001
AVR	0.340	−0.046	−0.143, −0.050
W/H ratio	0.170	0.080	−0.036, 0.199
BMI (kg/m²)	0.150	−0.001	−0.003, 0.000
Gender^a
Female	<0.001	−0.044	−0.057, −0.031
Male
Diabetes^a
No
Yes	0.072	−0.026	−0.053, 0.002
Hypertension^a
No
Yes	<0.001	−0.032	−0.045, 0.018

P-value = statistical significance of the association
CI = confidence interval
Coefficient β = Regression Coefficient (un-standardized Beta)
SBP systolic blood pressure, DBP diastolic blood pressure, IOP intraocular pressure, AL axial length, DA disc area, CRAE central retinal arteriolar equivalent, CRVE central retinal venular equivalent, AVR CRAE/CRVE ratio, W/H ratio Waist-to-hip ratio, BMI body-mass-index
^aNote: Gender, diabetes, hypertension was analyzed by mixed linear model

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