Abstract
Background/Objectives
To evaluate biometric changes throughout the anterior chamber during accommodation and presbyopia using single image acquisition swept-source anterior-segment optical coherence tomography (AS-OCT).
Subject/Methods
Anterior-segment images were obtained using a new swept-source AS-OCT device (ANTERION, Heidelberg Engineering) from healthy volunteers (n = 71) across two centers in this prospective observational case series. In one image acquisition, cornea through posterior lens, including the ciliary muscle on both sides of the right eye, was imaged. Subjects undertook no accommodative effort and −1, −3, and −5 D of target vergence. Two-way repeated measures ANOVA modeling was performed for ciliary muscle measurements, lens parameters, aqueous depth (AD), and pupil diameter (PD). The first ANOVA factor was accommodative stimuli, and the second factor included age and refractive status.
Results
Maximum ciliary muscle thickness increased with accommodative stimuli (p < 0.001), while the distance from the scleral spur to the maximal point on the ciliary muscle and posterior ciliary muscle thickness (CMT2) decreased (p < 0.001–0.002). Older individuals showed no accommodative changes for ciliary muscle parameters, lens thickness, lens vault, PD, and AD (p = 0.07–0.32). Younger- and middle-aged eyes showed statistically significant accommodative structural alterations for these endpoints (p < 0.001–0.002), but with different patterns, including early loss of CMT2 contraction in middle-aged eyes. Within the middle-aged group, myopic eyes maintained better capacity for accommodative structural change.
Conclusions
Swept-source AS-OCT demonstrated multiple simultaneous anterior-segment biometric alterations in single acquisition images, including early loss of posterior ciliary muscle function and better maintained capacity for anterior-segment structural change in myopia.
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Acknowledgements
This study was supported by China Scholarship Council Grant (#201808110001), Capital Characteristic Clinic Project of Beijing (Z18110000171808) [XX]. AGS MAPS Award (BYX); NIH NEI R01EY030501 [ASH] and K23EY029763 [BYX]; Research to Prevent Blindness Career Development Award 2016 [ASH]; and an unrestricted grant from Research to Prevent Blindness [UCLA and USC]. The sponsor or funding organization had no role in the design or conduct of this research.
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XX was responsible for experimental design, data acquisition, data analyses, creation of figures/tables, and preparation of the manuscript. WS was responsible for data analyses, creation of figures, and preparation of the manuscript. GC was responsible for experimental design, data acquisition, data analyses, and preparation of the manuscript. JYL was responsible for data analyses and preparation of the manuscript. AS and AP were responsible for data acquisition and preparation of the manuscript. FY was responsible for statistical analyses. VC was responsible for data analyses and preparation of the manuscript. SRS, BYX, and ASH were responsible for experimental design, data analyses, and preparation of the manuscript.
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ASH and BYX were loaned the ANTERION from Heidelberg Engineering for the purpose of research. ASH, SRS, and BYX received research support from Heidelberg Engineering.
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Xie, X., Sultan, W., Corradetti, G. et al. Assessing accommodative presbyopic biometric changes of the entire anterior segment using single swept-source OCT image acquisitions. Eye 36, 119–128 (2022). https://doi.org/10.1038/s41433-020-01363-3
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DOI: https://doi.org/10.1038/s41433-020-01363-3
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