Fig. 3: Structural and functional findings from the right eye of a 62-year-old (group 2) patient with choroideremia (CHM). | Eye

Fig. 3: Structural and functional findings from the right eye of a 62-year-old (group 2) patient with choroideremia (CHM).

From: Prospective deep phenotyping of choroideremia patients using multimodal structure-function approaches

Fig. 3

a En face optical coherence tomography angiogram (OCTA) of the choriocapillaris (CC). b En face OCT image of the ellipsoid zone (EZ) slab. Preserved areas of CC and EZ are highlighted in red and outlined by yellow dashes in a and b, respectively. c Fundus autofluorescence (FAF) image with area of preserved AF outlined in yellow. Relative preservation of retinal tissue can be observed on the temporal side of the fovea, as compared to the more degenerated nasal side. The central retinal island appears significantly smaller in this patient as compared to the younger patient in Fig. 2. The cross-sectional OCT image in d corresponds to the red dashed line in b. Cystoid macular oedema can be detected outside the nasal edge of the central retinal island. e MAIA colour-coded mesopic sensitivity map. More extensive loss of macular sensitivity can be detected in this eye when compared to the younger patient. f Severely diminished/non-measurable electroretinogram recordings of photopic flash (top) and flicker stimulations (down), respectively. g Dark adaptometry illustrated the defective dark adaptation and extensively-prolonged rod intercept time in eye with CHM.

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