Abstract
Background
To compare the accuracy of recently developed modern intraocular lens (IOL) power formulas (Barrett Universal II, Kane and VRF-G) with existing IOL power formulas in eyes with an axial length (AL) ≤ 22 mm.
Methods
This analysis comprised 172 eyes of 172 patients operated on by one surgeon (LT) with one IQ SN60WF (Alcon Labs, Fort Worth, TX, USA) hydrophobic lens. Ten IOL formulas were evaluated: Barrett Universal II (BUII), Haigis, Hoffer Q, Holladay 1, Holladay 2, Kane, SRK/T, T2, VRF and VRF-G. The median absolute error (MedAE), mean absolute error (MAE), standard deviation (SD) and all descriptive statistics were evaluated. Percentages of eyes with a prediction error within ±0.25 D, ±0.50 D, ±0.75 D and ±1.00 D were calculated using standard optimised constants for the entire range of axial lengths.
Results
The VRF-G, Haigis and Kane produced the smallest MedAE among all formulas (0.242 D, 0.247 D and 0.263 D, respectively) and had the highest percentage of eyes with a PE within ±0.50 D (75.67%, 73.84% and 75.16%, respectively). The Barrett was less accurate (0.298 D and 68.02%, respectively). Statistically significant differences were found predominantly between the VRF-G (P < 0.05), Kane (P < 0.05) and Haigis (P < 0.05) and all other formulas. The percentage of eyes with a PE within ±0.50 D ranged from 66.28% to 75.67%.
Conclusions
In eyes with AL ≤ 22.0 mm, the VRF-G, Haigis and Kane were the most accurate predictors of postoperative refraction, and the Barrett formula was less predictable.
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Acknowledgements
Larysa Tutchenko, MD, PhD for performing all phacoemulsification operations.
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OVV was responsible for designing the study protocol, writing the protocol and report, conducting the calculation and statistical analysis, collecting and analysing data, interpreting results, updating reference lists and creating VRF and VRF-G formulas. LT was responsible for performing all operation, designing the review protocol and screening potentially eligible studies. She contributed to writing the draft of the article and analysing data. DHF was responsible for collecting and analysing data, writing the protocol and report and interpreting results, updating reference lists.
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Voytsekhivskyy is the inventor and sole owner of the VRF and VRF-G formulas and has a patent on the method of estimation of postoperative lens position (ELP) and the calculation of optical power and is the author and copyright holder of a computer programme ViOL Commander. Tutchenko declares no potential conflict of interest. Hipólito-Fernandes declares no potential conflict of interest. We have disclosed those interests fully to the journal, and have in place an approved plan for managing any potential conflicts arising from this arrangement.
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Voytsekhivskyy, O.V., Tutchenko, L. & Hipólito-Fernandes, D. Comparison of the Barrett Universal II, Kane and VRF-G formulas with existing intraocular lens calculation formulas in eyes with short axial lengths. Eye 37, 120–126 (2023). https://doi.org/10.1038/s41433-021-01890-7
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DOI: https://doi.org/10.1038/s41433-021-01890-7
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