Table 1 Key details of included studies.

Bagchi et al. 2019 [26]

Retrospective audit of patients who presented to a retinal clinic in the United Kingdom with high myopia (<−6D or AL > 26 mm) and new onset visual disturbance who received FA, OCTA and SD-OCT imaging.

Excluded patients who did not receive all three imaging modalities. Excluded patients with poor quality images. Excluded patients with other co-existing major ocular conditions.

27 eyes of 26 patients (18 female, 6 male)

Mean age 47.7 ± 19.7 years

OCTA vs FA:

Sensitivity 19/23, specificity 3/4 SD-OCT vs FA: Sensitivity 23/23, specificity 0/4

Milani et al. 2016 [24]

Retrospective audit of patients seen at a research hospital in Italy with recent vision deterioration, pathologic myopia (<−6D and staphyloma) and suspected mCNV who received near infrared, autofluorescence, FA and SD-OCT imaging at first presentation.

Excluded patients who did not receive all four imaging modalities. Excluded patients with poor quality images. Excluded patients who had previous vitreoretinal surgery, diabetes, signs of age-related macular degeneration, or vitreoretinal interface-related pathologies.

65 eyes of 62 patients (44 female, 21 male)

Mean age 66.72 years, range 18–89

Mean refraction −9.72D, range −6 to −22

SD-OCT vs FA:

Sensitivity 48/49, specificity 16/16

Miyata et al. 2016 [25]

Prospective study of consecutive patients who presented to a university ophthalmology clinic in Japan with pathologic myopia (<−6D or AL > 26 mm, plus chorioretinal abnormalities) and treatment naïve exudative lesions.

Patients with OCTA images of insufficient quality were excluded from analysis.

28 eyes of 26 patients (22 female, 4 male)

Included in analysis:

21 eyes of 20 patients (17 female, 3 male)

Mean age 63.0 ± 13.6 years

OCTA vs FA:

Sensitivity 16/17, specificity 4/4

Querques et al. 2017 [28]

Retrospective audit of patients who presented to a university hospital’s retinal clinic in Italy with pathologic myopia (<−8D or AL > 26.5 mm, plus characteristic degenerative changes of the sclera/choroid/retina) who were diagnosed with mCNV using FA.^a An additional cohort of patients with pathologic myopia and no evidence of mCNV were enrolled as a negative control group.

Excluded patients with co-existing retinal conditions, history of ocular inflammation in the study eye, significant media opacities, or large haemorrhage. Patients with OCTA images of insufficient quality or who did not have FA performed on the same day as OCTA were excluded from analysis.

Negative control group: Excluded patients with co-existing retinal conditions, or previous ocular treatments in the study eye.

36 eyes of 28 patients (23 female, 5 male)

Included in analysis:

21 eyes of 17 patients (14 female, 3 male)

Mean age 57.8 ± 14.5 years

Negative control group:

32 eyes of 32 patients (27 female, 5 male)

Mean age 56.2 ± 14.4 years, range 26–84

OCTA vs FA^a:

Sensitivity 19/21, specificity 30/32

Su et al. 2014 [27]

Prospective study of patients who presented to a macular service centre in China with high myopia (<−6D and AL > 26.5 mm) and myopic maculopathy.

Excluded patients with other retinal or choroidal diseases, or dense cataracts.

69 eyes of 42 patients (23 female, 19 male)

Mean age 47.3 ± 17.3 years, range 20–79

SD-OCT vs FA:

Sensitivity 16/16, specificity 53/53