Abstract
Objectives
Major ocular diseases share common risk factors and pathogeneses with stroke. This study aimed to evaluate the relation between stroke and ocular diseases including visual impairment (VI).
Methods
The cross-sectional study investigated the prevalence and associations of VI and major eye diseases with stroke among 4570 participants in the 2005–2008 National Health and Nutrition Examination Survey (NHANES). The association of VI and major ocular diseases with stroke were estimated using univariate and multivariate logistic regression crude models and models adjusted for demographics and clinical factors. We also conducted stratified analyses by diabetes and hypertension status.
Results
VI was associated with stroke, and the odds ratios (ORs) for mild and moderate and severe visual impairment (MSVI) were 6.79 (95% confidence interval (CI): 2.44–18.88) and 9.46 (95% CI: 2.19–40.94) after adjusting for age and gender (all P < 0.05). Ocular disease was associated with stroke with OR reaching 5.54 (95% CI: 1.83–16.74), and the OR was 9.61 (95% CI: 3.05–30.23) for stroke patients suffering DR after adjusting for age and gender (all P < 0.05). After multivariable adjustment, the associations were limited to mild VI (OR = 10.00, 95% CI: 3.16–30.58), MSVI (OR = 8.57, 95% CI: 1.58–43.36), and any ocular disease (OR = 5.18, 95% CI: 1.46–18.42) (all P < 0.05). Significant associations between stroke and any ocular disease and DR were observed among diabetic participants, and significant relation between stroke and MSVI was found among hypertension patients.
Conclusions
The sample of the US population demonstrates significant associations between VI and major ocular disease with stroke.
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Data availability
Data supporting the findings of this study are available from https://www.cdc.gov/nchs/nhanes/index.htm.
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Funding
This study was supported by National Natural Science Foundation of China (82141128); The Capital Health Research and Development of Special (2020–1–2052); Science & Technology Project of Beijing Municipal Science & Technology Commission (Z201100005520045, Z181100001818003).
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W.B. Wei, H.Y Li and Q. Yang designed the study, H.Y Li, L. Dong and Q. Yang wrote the manuscript. H.Y Li, W.D Zhou, H.T Wu, Y.F Li, and R. H Zhang collected the data and conducted the analyses, W.B. Wei edited and revised the manuscript. All authors have approved the submitted version and agreed with the contributions declarations.
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Li, HY., Yang, Q., Dong, L. et al. Visual impairment and major eye diseases in stroke: a national cross-sectional study. Eye 37, 1850–1855 (2023). https://doi.org/10.1038/s41433-022-02238-5
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DOI: https://doi.org/10.1038/s41433-022-02238-5
