Table 1 Clinical characteristics of included studies.
From: Choroidal vascularity index and choroidal thickness: potential biomarkers in retinitis pigmentosa
Study | Study design | Number of eyes (number of patients) | Primary and secondary endpoint | Results | Secondary outcomes |
|---|---|---|---|---|---|
Akay et al. 2019 [23] | Prospective case-control | Cases: 35 (35) Controls: 40 (40) | CT in RP patients with respect to controls | Lower CT in all measurement areas | Â |
Aknin et al. 2018 [24] | Prospective case-control | Cases: 40 (20) Controls: 40 (20) | CT in RP patients with respect to controls Association between CT and visual acuity | Lower CT in all measurement areas | Decreased visual acuity significantly associated with reduction of CT |
Ayton et al. 2013 [25] | Prospective case-control | Cases: 67 (42) Controls: 35 (22) | CT in RP patients with respect to controls Association between CT, visual acuity and duration of disease. | Lower CT in all measurement areas | Reduction of CT with poorer visual acuity or longer duration of symptoms |
Dhoot et al. 2013 [26] | Prospective case-control | Cases: 21 (21) Controls: 25 (25) | CT in RP patients with respect to controls Association between CT, visual acuity, and central retinal thickness | Lower CT in all measurement areas | No correlation between CT and visual acuity or central retinal thickness |
Son et al. 2019 [27] | Retrospective cross-sectional | Cases: 291 (149) Controls: 68 (68) | Correlations between VFI and BCVA and structural indices (CFT, EZ length, and CT) | Lower CT in all measurement areas | No correlation between CT and VFI or BCVA |
Sodi et al. 2018 [28] | Retrospective cross-sectional | Cases: 291 (39) Controls: 68 (73) | CT in RP patients respect to controls Association between CT, visual acuity, age, age at disease onset, duration, macular thickness, visual field loss, ERG | Lower CT in all measurement areas | No correlation between CT and clinical parameters |
Chhablani et al. 2016 [29] | Prospective observational study | Cases: 88 (69) Controls: 188 (104) | CT in RP patients with respect to controls Association between CT, visual acuity, outer retinal structures, and age | No difference of CT in RP respect to control group | Thinning of CT with age No correlation between CT and visual acuity or clinical parameters |
Tan et al. 2018 [30] | Prospective observational | Cases: 35 (35) Controls: 26 (26) | CVI and CT in RP patients with respect to controls | Lower CVI and increase in CT in RP patient | Â |
Wei at al. 2019 [31] | Retrospective cross-sectional | Cases: 46 (26) Controls: 64 (32) | CVI in retinal dystrophies | Lower CVI in RP patient respect to controls | Â |
Iovino et al. 2019 [32] | Retrospective cross-sectional | Cases: 159 (159) divided in two groups based on the presence or the absence of CME (resp. 67 vs 92 eyes) | CVI and CT in RP patients with and without CME | Increased CT and lower CVI in patients with CME respect to those without CME | Â |
Shen et al. 2020 [33] | Prospective observational | Cases: 34 (63) Controls: 34 (17) | CVI and CC defects in RP patients with respect to controls | Lower CVI in RP patient respect to controls. Presence of CC defects | No correlation between CVI and visual acuity or retinal structures changes |
Cetin et al. 2020 [34] | Prospective observational | Cases: 69 (36) | Study of CT, CVI, presence of DRIL, ERM and disruption of ELM and EZ in RP patients | Higher CVI in patients with disruption of outer retinal segment integrity. No correlation between CT and retinal alterations | No correlation between visual acuity and CT or CVI |
Kawano et al. 2017 [35] | Retrospective cross-sectional | Cases: 37 (24) Controls: 35 (35) | Luminal area and stromal area defects in RP patients respect to controls Luminal area and stromal area inside and outside HAF ring | Luminal area reduced in RP patients respect to controls | In RP patients luminal area is reduced outside HAF respect to inside HAF |
Egawa et al. 2019 [36] | Retrospective observational case series | Cases: 100 (100) Controls: 60 (60) | Luminal area and stromal area in inner and outer subfoveal choroid Correlation between luminal area and stromal area and visual acuity | Significant smaller choroidal Luminal area, in the inner choroid in eyes with RP | Correlation of luminal area with best corrected visual acuity, foveal sensitivity, EZ width, and central foveal thickness |
