Abstract
Background
To explore the relationship between the choroid vascular index (CVI) and best corrected visual acuity (BCVA) in a young population with high myopia (HM).
Subjects/Methods
Three hundred twenty-six patients with HM were recruited. All subjects underwent a comprehensive ophthalmic examination and enhanced depth imaging optical coherence tomography (EDI-OCT). The horizontal and vertical subfoveal choroidal areas within a 3-mm diameter centred over the fovea were selected. Choroid thickness (ChT), horizontal and vertical total choroidal area (TCAH and TCAV), luminal area (LAH and LAV) and stromal area (SAH and SAV) within the 3-mm diameter were assessed. CVI values (CVIH and CVIV), defined as the ratio of LA to TCA, were also calculated. The correlations among choroid parameters and ocular characteristics were analysed.
Results
The median age, spherical equivalent (SE) and BCVA were 22.4 years, −10.1 dioptres and 0.099 logMAR, respectively. The ChT was thickest on the temporal and superior sides of the macula and thinnest in the nasal region, with a significant difference. The value of CVIH was significantly greater than that of CVIV because SCAH was smaller than SCAV. Both CVIH and CVIV were closely correlated with BCVA in all patients.
Conclusions
The CVI is significantly related to BCVA but is not affected by age, axial length or SE, suggesting that the CVI could be used as an adjunct tool for assessing the visual acuity status in patients with HM.
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Data availability
The data supporting the results of the current study can be found within the article and the supplementary material.
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Funding
This work was supported by the Clinical Research Plan of SHDC (SHDC2020CR2041B), the National Natural Science Foundation of China (81770944), the Foundation for the Shanghai Key Laboratory of Visual Impairment and Restoration (12DZ2260500) and the Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences The sponsor or funding organization had no role in the design or conduct of this research.
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RY-H, ZQ-Y and QL-W designed the project; RY-H, WT-C, XY-D and QL-W were responsible for obtaining and analysing raw data. Construction of tables and figures were performed by RY-H and QL-W; RJ, QC and GZ-X supervised the complete project and validated the final results; RY-H and QL-W wrote the first draft of the manuscript. All authors have read and agreed to the published version of the manuscript.
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Han, R., Chang, W., Ding, X. et al. The choroid vascular index and its association with visual acuity in children and young adults with high myopia. Eye 37, 2542–2547 (2023). https://doi.org/10.1038/s41433-022-02369-9
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DOI: https://doi.org/10.1038/s41433-022-02369-9
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