Table 1 Mean rate of change in GA area from baseline by month, mixed-model for repeated measures (MMRM) analysis square root transformation.
Cohort | Avacincaptad pegol 2 mg | Shama | Avacincaptad pegol 4 mg | Shamb |
|---|---|---|---|---|
GA at baseline (mm), Mean (SD) | 2.618 (0.7001) | 2.633 (0.7009) | 2.715 (0.7320) | 2.636 (0.7091) |
n at baseline | 67 | 110 | 83 | 84 |
GA at month 6 (mm), Mean (SD) | 2.772 (0.7183) | 2.865 (0.7154) | 2.930 (0.7483) | 2.886 (0.7145) |
6-month least squares Mean (SE) | 0.123 (0.043) | 0.178 (0.042) | 0.145 (0.039) | 0.198 (0.037) |
6-month difference, (% Difference [95% CI]) | 0.054 (30.68 [0.006; 0.103]) | 0.053 (26.93 [0.007; 0.100]) | ||
n at month 6 (% of baseline) | 58 (86.6) | 92 (83.6) | 63 (75.9) | 73 (86.9) |
GA at month 12 (mm), Mean (SD) | 3.032 (0.6643) | 3.119 (0.7182) | 3.083 (0.7713) | 3.143 (0.7201) |
12-month least squares Mean (SE) | 0.287 (0.073) | 0.384 (0.071) | 0.301 (0.070) | 0.418 (0.067) |
12-month difference, (% Difference [95% CI]) | 0.097 (25.31 [0.017; 0.177]) | 0.117 (28.04 [0.033; 0.202]) | ||
n at Month 12 (% of baseline) | 49 (73.1) | 90 (81.8) | 55 (66.3) | 72 (85.7) |
GA at month 18 (mm), Mean (SD) | 3.063 (0.5821) | 3.282 (0.7563) | 3.108 (0.8158) | 3.294 (0.7641) |
18-month least squares Mean (SE) | 0.430 (0.092) | 0.599 (0.089) | 0.391 (0.087) | 0.559 (0.083) |
18-month difference, (% Difference [95% CI]) | 0.168 (28.11 [0.066; 0.271]) | 0.167 (29.97 [0.062; 0.273]) | ||
n at Month 18 (% of baseline) | 41 (61.2) | 78 (70.9) | 45 (54.2) | 64 (76.2) |
