Table 1 Using optical coherence tomography parameters to monitor visual field progression in glaucoma.

pRNFLT^a

Sehi et al. 2013 [4]

∙ First follow-up visit which reached a significant negative visual field index slope over time (p < 0.05)

∙ 310 glaucoma suspect or pre-perimetric eyes & 177 perimetric eyes

∙ MD: −3.82 ± 4.28; −0.23 ± 1.04 dB, respectively

∙ Average and superior RNFL losses were correlated with visual field index loss in multivariate Cox models.

Yu et al. 2016 [3]

∙ 24-2 VF^b

∙ 240 eyes of 139 patients with POAG^c

∙ MD⁴: −9.5 ± 9.1 dB

∙ Early Manifest Glaucoma Trial or pointwise linear regression criteria

∙ Progressive RNFL thinning predicted incidence of VF progression using both event and trend-based analysis after controlling for baseline covariates.

mGCCT^d

Anraku et al. 2014 [11]

∙ Fast progressors (MD < −0.4 dB/year) versus slow progressors (MD ≥ −0.4 dB/year)

∙ 56 POAG patients with non-advanced glaucoma

∙ MD: −3.26 ± 3.0 dB

∙ Baseline inferior mGCCT is associated with disease progression.

Zhang et al. 2016 [10]

∙ Significant progression (p < 0.05) on Humphrey Progression Analysis or significant negative slope for VF index

∙ 277 eyes of 188 participants from Advanced Imaging for Glaucoma Study

∙ MD: −4.76 ± 5.13 (non-progressors) and −4.99 ± 4.21 dB (progressors)

∙ GCC focal loss volume was the most significant structural predicting factor for VF loss in a multivariable Cox model.

mGCIPLT^e

Shin et al. 2019 [13]

∙ Three consecutive abnormal VFs

∙ 541 eyes of 357 glaucoma suspect patients

∙ MD: −0.79 ± 1.34 dB

∙ Eyes with progressive GCIPL thinning had a significantly higher risk of developing VF defects.

Lee et al. 2017 [12]

∙ Mean deterioration of ≥3 dB compared with 2 baseline values, (observed twice)

∙ 65 POAG patients, non-progressors (38) and progressors (27)

∙ “Likely progression” according to event analysis

∙ Mild (MD ≥ −6 dB) or moderate to advanced (MD < −6 dB)

∙ Global and sectoral GCIPL thinning were significantly faster for POAG patients who were classified as progressors

Shin et al. 2017 [14]

∙ Early manifest glaucoma trial criteria or linear regression analysis of the VF index

∙ 196 eyes of 123 POAG patients,

∙ Patients divided into mild (MD ≥ −6dB) or moderate to advanced groups (MD < −6dB) based on VF defects

∙ Rate of change of average GCIPL thinning was significantly higher in progressors compared to non-progressors. Rate of change in RNFL thinning did not differ significantly between progressors and non-progressors in moderate to advanced group.

Shin et al. 2020 [15]

∙ Guided progression analysis

∙ 104 POAG patients with high myopia and 104 patients who were matched with VF severity-POAG without high myopia

∙ MD: −6.36 ± 6.22 dB (high myopia) and −5.35 ± 5.11 dB (controls)

∙ Highly myopic eyes with progressive GCIPL thinning were at higher risk for developing VF progression after adjusting for intraocular pressure

BMO^f parameters

Pollet-Villard et al. 2014 [16]

∙ 24-2 VF

∙ 142 eyes of 142 subjects with glaucoma, glaucoma suspect, or controls

∙ No progression analysis

∙ MD: −8.28 ± 8.64 dB (glaucoma), −1.56 ± 2.22 dB (suspect), −1.60 ± 3.02 dB (controls)

∙ Structure-function relationships between BRO-MRW^g and VF sensitivity were higher than with pRNFL thickness.

Imamoglu et al. 2017 [17]

∙ 10-2 VF

∙ 33 eyes of 29 patients with advanced glaucoma

∙ No progression analysis

∙ MD: −14.4 (−23.8 to −11)

∙ Sectoral BMO-MRW measurements were highly correlated with VF sensitivities on the 10-2 test

Choi et al. 2021 [18]

∙ Visual field index using the Humphrey Field Analyzer

∙ 121 eyes (73 with POAG and 48 normal eyes)

∙ No progression analysis

∙ BMO-minimum rim area decreased more rapidly and preceded changes in RNFLT and visual field index during glaucoma progression