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Morphologic features of iris in highly myopic eyes based on a novel swept-source optical coherence tomography

Eye volume 38, pages 3443–3449 (2024)Cite this article

Subjects

Abstract

Background

To investigate the morphologic features of iris in the highly myopic (HM) eyes using a novel swept-source optical coherence tomography (SS-OCT).

Methods

In this retrospective case-control study, 100 eyes of 100 patients scheduled to have cataract surgery were included, categorized into the control (22 mm< AL < 24.5 mm) and HM (AL ≥ 26 mm) groups. Iris volume (IV), area of anterior iris surface (IS), area of posterior IS, and average iris thickness (IT), as well as anterior chamber volume (ACV) and trabecular-iris space at 500 µm (TISA 500) were evaluated using SS-OCT. The associated factors with morphologic features of iris were also investigated.

Results

The HM group showed significantly larger IV and area of anterior and posterior IS than the control group (all P < 0.001), while no difference was identified in IT between the groups. Similar trend in IV was seen in the superior and nasal segments, and area of anterior and posterior IS showed similar trends in all segments except the temporal segment. The IV, area of anterior and posterior IS were all positively correlated with AL (all P < 0.001). Multivariate linear regression revealed that a larger IV was associated with greater ACV. Both larger areas of anterior IS and posterior IS were associated with male, longer AL, greater ACV, and smaller TISA 500.

Conclusions

The HM eyes showed larger IV and area of IS than the control eyes, indicating a coronal expansion of the iris with AL. Iris morphology correlated with anterior chamber angle configuration.

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Fig. 1: Representative three-dimensional images of the iris based on the SS-OCT scan.
Fig. 2: Iris features distribution across eight segments.
Fig. 3: The correlation between iris volume (IV) and ocular parameters.

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Data availability

The data supporting the findings of this study are not publicly accessible due to privacy concerns and can be available from the corresponding author upon reasonable request.

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Acknowledgements

We express our sincere gratitude to all the team members and staff who contributed to this study but are not listed as authors. Their generous grants have been crucial in the advancement of our work.

Funding

This article was supported by research grants from the National Natural Science Foundation of China (82122017, 82271069, 81870642, 82371040, 81970780, 81470613, 81670835 and 82301188), Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission (23Y11909800 and 21S31904900), Clinical Research Plan of Shanghai Shenkang Hospital Development Center (SHDC12020111), Shanghai Municipal Key Clinical Specialty Programn (shslczdzk01901). Outstanding Youth Medical Talents of Shanghai “Rising Stars of Medical Talents” Youth Development Program (20244Z00150).

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Author notes

  1. These authors contributed equally: Ching Kang, Jiaqi Meng, Lan Wang.

Authors and Affiliations

  1. Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China

    Ching Kang, Jiaqi Meng, Lan Wang, Chao Chen, Yuxi Chen, Wenwen He, Keke Zhang, Yi Lu, Yanwen Fang & Xiangjia Zhu

  2. NHC Key Laboratory of Myopia and Related Eye Diseases, Shanghai, 200031, China

    Ching Kang, Jiaqi Meng, Lan Wang, Chao Chen, Yuxi Chen, Wenwen He, Keke Zhang, Yi Lu, Yanwen Fang & Xiangjia Zhu

  3. Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Science, Shanghai, 200031, China

    Ching Kang, Jiaqi Meng, Lan Wang, Chao Chen, Yuxi Chen, Wenwen He, Keke Zhang, Yi Lu, Yanwen Fang & Xiangjia Zhu

  4. Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China

    Ching Kang, Jiaqi Meng, Lan Wang, Chao Chen, Yuxi Chen, Wenwen He, Keke Zhang, Yi Lu, Yanwen Fang & Xiangjia Zhu

Authors
  1. Ching Kang
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  2. Jiaqi Meng
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  3. Lan Wang
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  8. Yi Lu
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  9. Yanwen Fang
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Contributions

XZ revised the manuscript, obtained funding, and supervised the process. Yanwen Fang revised the manuscript and supervised the process. CK, JM and LW collected, analysed the patient data and wrote the manuscript. CC and YC collected the patient data and assisted in drafting the manuscript. WH and KZ read and revised the manuscript. YL obtained funding, read and revised the manuscript. CK, JM and LW contributed equally to this work. All authors approved the manuscript and this submission.

Corresponding authors

Correspondence to Yanwen Fang or Xiangjia Zhu.

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Kang, C., Meng, J., Wang, L. et al. Morphologic features of iris in highly myopic eyes based on a novel swept-source optical coherence tomography. Eye 38, 3443–3449 (2024). https://doi.org/10.1038/s41433-024-03321-9

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