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Optic neuritis in Rosai Dorfman disease

Abstract

A 55-year-old man while being evaluated for unexplained weight loss was found to have multiple metabolically active lymph nodes on positron emission tomography-computed tomography (PET-CT) scan, and biopsy from right axillary lymph node demonstrated multiple histiocytes with emperipolesis with S100 positivity, consistent with Rosai-Dorfman disease.

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Fig. 1: Microphotograph shows reactive lymphoid follicles with marked expansion of sinusoids.

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Concept and design: Dr Swati Phuljhele and Dr Himani Thakur. Acquisition of the histopathology image: Dr Saumyaranjan Mallick. Drafting of the manuscript: Dr Himani Thakur. Critical revision of the manuscript for important intellectual content: Dr Rohit Saxena and Dr Rebika Dhiman. The manuscript is an honest work and has been approved by all the authors.

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Correspondence to Swati Phuljhele.

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Phuljhele, S., Thakur, H., Saxena, R. et al. Optic neuritis in Rosai Dorfman disease. Eye 39 (Suppl 1), 102–103 (2025). https://doi.org/10.1038/s41433-024-03369-7

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  • DOI: https://doi.org/10.1038/s41433-024-03369-7

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