Table 1 a Fluid reduction and retreatment interval for all eyes and all eyes with fluid greater than 10-nL after successive treatments of faricimab. We see a stable proportion of all eyes near 50% for improvements in total retinal fluid with increases in treatment intervals. In all eyes with fluid greater than 10-nL, we see over 60% of patients demonstrating improvement in total retinal fluid with increases in treatment intervals; b Fluid reduction and retreatment interval for all eyes previously treated with aflibercept after successive treatments of faricimab. We see a stable proportion of eyes above 50% for improvements in total retinal fluid with increases in treatment intervals. In eyes with fluid greater than 10-nL, we see over 57% of patients demonstrating improvement in total retinal fluid with increases in treatment intervals; c Fluid reduction and retreatment interval for all treatment-naive eyes after successive treatments of faricimab. We see a stable proportion of eyes above 80% for improvements in total retinal fluid. In eyes with fluid greater than 10-nL, we see over 85% of patients demonstrating improvement in total retinal fluid.
(a) All Eyes | ||||||
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After Treatment # | Eyes (n/N) | All Eyes | Eyes (n/N) | Eyes with > 10-nL Fluid | ||
% with fluid reduction | Mean Retreatment Interval (days) | % with fluid reduction | Mean Retreatment Intervals (days) | |||
1 | 260/521 | 49.9% | 53.0 | 180/258 | 69.8% | 49.5 |
2 | 229/421 | 54.4% | 53.4 | 169/224 | 75.5% | 56.6 |
3 | 179/345 | 51.9% | 56.6 | 135/199 | 67.8% | 55.5 |
4 | 144/280 | 51.4% | 57.1 | 112/169 | 66.3% | 54.3 |
5 | 106/203 | 52.2% | 61.5 | 81/135 | 60.1% | 62.9 |
(b) Previously Treated with Aflibercept | ||||||
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After Treatment # | Eyes (n/N) | All Eyes | Eyes (n/N) | Eyes with > 10-nL Fluid | ||
% with fluid reduction | Mean Retreatment Interval (days) | % with fluid reduction | Mean Retreatment Intervals (days) | |||
1 | 148/296 | 50.0% | 49.3 | 96/142 | 67.6% | 49.6 |
2 | 136/264 | 51.5% | 52.2 | 93/131 | 71.0% | 50.7 |
3 | 121/236 | 51.3% | 54.5 | 89/137 | 65.0% | 51.4 |
4 | 103/201 | 51.4% | 55.8 | 77/116 | 66.4% | 54.1 |
5 | 77/147 | 52.2% | 60.4 | 53/92 | 57.6% | 58.7 |
(c) Treatment-naive | ||||||
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After Treatment # | Eyes (n/N) | All Eyes | Eyes (n/N) | Eyes with > 10-nL Fluid | ||
% with fluid reduction | Mean Retreatment Interval (days) | % with fluid reduction | Mean Retreatment Intervals (days) | |||
1 | 40/49 | 81.6% | 41.8 | 31/34 | 91.2% | 38.1 |
2 | 34/37 | 91.9% | 39.2 | 28/29 | 96.6% | 64.2 |
3 | 21/26 | 80.8% | 55.3 | 17/20 | 85.0% | 71.3 |
4 | 16/21 | 76.2% | 62.8 | 14/16 | 87.5% | 54.7 |
5 | 13/15 | 86.7% | 51.3 | 12/14 | 85.7% | 67.3 |