Table 1 a Fluid reduction and retreatment interval for all eyes and all eyes with fluid greater than 10-nL after successive treatments of faricimab. We see a stable proportion of all eyes near 50% for improvements in total retinal fluid with increases in treatment intervals. In all eyes with fluid greater than 10-nL, we see over 60% of patients demonstrating improvement in total retinal fluid with increases in treatment intervals; b Fluid reduction and retreatment interval for all eyes previously treated with aflibercept after successive treatments of faricimab. We see a stable proportion of eyes above 50% for improvements in total retinal fluid with increases in treatment intervals. In eyes with fluid greater than 10-nL, we see over 57% of patients demonstrating improvement in total retinal fluid with increases in treatment intervals; c Fluid reduction and retreatment interval for all treatment-naive eyes after successive treatments of faricimab. We see a stable proportion of eyes above 80% for improvements in total retinal fluid. In eyes with fluid greater than 10-nL, we see over 85% of patients demonstrating improvement in total retinal fluid.

From: Retinal fluid quantification using a novel deep learning algorithm in patients treated with faricimab in the TRUCKEE study

(a) All Eyes

After Treatment #

Eyes (n/N)

All Eyes

Eyes (n/N)

Eyes with > 10-nL Fluid

% with fluid reduction

Mean Retreatment Interval (days)

% with fluid reduction

Mean Retreatment Intervals (days)

1

260/521

49.9%

53.0

180/258

69.8%

49.5

2

229/421

54.4%

53.4

169/224

75.5%

56.6

3

179/345

51.9%

56.6

135/199

67.8%

55.5

4

144/280

51.4%

57.1

112/169

66.3%

54.3

5

106/203

52.2%

61.5

81/135

60.1%

62.9

(b) Previously Treated with Aflibercept

After Treatment #

Eyes (n/N)

All Eyes

Eyes (n/N)

Eyes with > 10-nL Fluid

% with fluid reduction

Mean Retreatment Interval (days)

% with fluid reduction

Mean Retreatment Intervals (days)

1

148/296

50.0%

49.3

96/142

67.6%

49.6

2

136/264

51.5%

52.2

93/131

71.0%

50.7

3

121/236

51.3%

54.5

89/137

65.0%

51.4

4

103/201

51.4%

55.8

77/116

66.4%

54.1

5

77/147

52.2%

60.4

53/92

57.6%

58.7

(c) Treatment-naive

After Treatment #

Eyes (n/N)

All Eyes

Eyes (n/N)

Eyes with > 10-nL Fluid

% with fluid reduction

Mean Retreatment Interval (days)

% with fluid reduction

Mean Retreatment Intervals (days)

1

40/49

81.6%

41.8

31/34

91.2%

38.1

2

34/37

91.9%

39.2

28/29

96.6%

64.2

3

21/26

80.8%

55.3

17/20

85.0%

71.3

4

16/21

76.2%

62.8

14/16

87.5%

54.7

5

13/15

86.7%

51.3

12/14

85.7%

67.3