Table 2 Multivariable associations between visual functions with ocular factors and AMD features in all participants.

From: Determinants of visual functions in patients with early and intermediate age-related macular degeneration: the PEONY study

 

BCVAa

LLVAa

LLDb

qAF value (per SD)

0.142

0.386

0.974

0.079 (−0.026 to 0.184)

0.048 (−0.060 to 0.155)

−0.002 (−0.127 to 0.123)

SFCT (per SD)

0.507

0.114

0.006

−0.034 (−0.133 to 0.066)

0.091 (−0.027 to 0.205)

−0.183 (−0.314 to −0.052)

RPE-BM volume (per SD)

0.077

0.338

0.877

−0.096 (−0.201 to 0.010)

−0.059 (−0.181 to 0.062)

−0.010 (−0.135 to 0.115)

ONL volume (per SD)

0.425

<0.001

<0.001

0.038 (−0.056 to 0.132)

0.229 (0.126 to −0.333)

−0.320 (−0.441 to −0.199)

Presence of nGA

0.029

<0.001

0.005

−0.314 (−0.594 to −0.033)

−0.577 (−0.892 to −0.262)

0.545 (0.172 to 0.918)

Presence of hyperTD

0.010

0.005

0.078

−0.283 (−0.495 to −0.071)

−0.353 (−0.595 to −0.111)

0.248 (−0.027 to 0.523)

Presence of HDL

0.170

0.094

0.194

−0.186 (−0.455 to 0.083)

−0.265 (−0.575 to 0.045)

0.243 (−0.122 to 0.607)

Presence of HRF

0.006

0.070

0.710

−0.300 (−0.513 to −0.087)

−0.229 (−0.475 to 0.017)

0.051 (−0.219 to 0.332)

Presence of drusen

<0.001

0.001

0.303

−0.565 (−0.809 to −0.321)

−0.396 (−0.675 to −0.117)

0.167 (−0.151 to 0.485)

Presence of refractile drusen

0.008

<0.001

0.003

−0.635 (−1.102 to −0.167)

−1.035 (−1.561 to −0.583)

0.966 (0.331 to −1.601)

Presence of CD

0.256

0.380

0.747

−0.382 (−1.040 to 0.276)

−0.338 (−1.092 to 0.416)

0.148 (−0.752 to 1.048)

Presence of SDD

0.567

<0.001

<0.001

−0.058 (−0.255 to 0.139)

−0.446 (−0.663 to −0.228)

0.600 (0.358 to −0.843)

Presence of hypo-AF

0.003

0.007

0.185

−0.480 (−0.793 to −0.167)

−0.499 (−0.859 to −0.139)

0.290 (−0.138 to 0.717)

  1. Values are P-values, beta values and 95% confidence interval. Values with P < 0.05 are highlighted in bold.
  2. BCVA best corrected visual acuity, CD cuticular drusen, HDL hyporeflective drusenoid lesions, HRF hyperreflective foci, hyperTD hypertransmission defect, hypo-AF hypo-autofluorescence, LLD low-luminance deficits, LLVA low-luminance visual acuity, nGA nascent geographic atrophy, ONL outer nuclear layer, qAF quantitative autofluorescence, RPE-BM retinal epithelium-Bruch’s membrane, SD standard deviation, SDD subretinal drusenoid deposits, SFCT subfoveal choroidal thickness.
  3. aAdjusted for age, gender and baseline AMD stage.
  4. bAdjusted for age and gender.
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