Fig. 2: Descriptive plots of hyporeflective clump size distribution.

The histogram/density plot a of HRC size shows a normal distribution. Grouping HRC size by type of lesion imaged b showed significantly larger HRCs over complete retinal pigment epithelium and outer retina atrophy (cRORA) compared to drusen (p < 0.001), and similarly, grouping HRC size by whether the cone mosaic was mostly intact c, showed that a mostly intact cone mosaic on the AOO image was associated with smaller HRCs (p < 0.001). The ○ represents mean, the □ median, and the bars the 95% confidence interval.