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The fragile cross-link: progressive corneal thinning in a Down’s syndrome

Eye (2026)Cite this article

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Fig. 1: Severe thinning post collagen crosslinking for keratoconus in a patient with Down's syndrome.

References

  1. Mathan JJ, Gokul A, Simkin SK, Meyer JJ, McGhee CN. Keratoconus in Down syndrome: prevalence, risk factors, severity and corneal tomographic characteristics. Clin Exp Ophthalmol. 2024;52:22–30.

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  2. Haseeb A, Huynh E, ElSheikh RH, ElHawary AS, Scelfo C, Ledoux DM, et al. Down syndrome: a review of ocular manifestations. Ther Adv Ophthalmol. 2022;14:25158414221101718.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Shroff Eye Centre, New Delhi, India

    Deepender Chauhan, Oishwarya Chakraborty & Ritu Arora

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  1. Deepender Chauhan
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  2. Oishwarya Chakraborty
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  3. Ritu Arora
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Contributions

DC: conceptualisation, patient management, manuscript writing and clinician in-charge. OC: Literature search, manuscript writing. RA: data retrieval, literature search, manuscript writing.

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Correspondence to Oishwarya Chakraborty.

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Chauhan, D., Chakraborty, O. & Arora, R. The fragile cross-link: progressive corneal thinning in a Down’s syndrome. Eye (2026). https://doi.org/10.1038/s41433-025-04199-x

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