Fig. 1 | Hypertension Research

Fig. 1

From: Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension

Fig. 1

Effect of candesartan (CAN) on mean arterial pressure (MAP) (a), heart rate (HR) (b), and plasma norepinephrine (NE) (c, d) in control and stress-induced hypertension (SIH) groups. The rats were anesthetized and implanted with ICV cannula for infusion of the AT1R antagonist CAN on the second day during stress in SIHR and in the control group. Arrows indicate infusion time. Values are expressed as mean ± SE and statistical analysis was performed by using one-way analysis of variance (ANOVA) coupled with Tukey’s multiple comparison test in c, d, and two-way ANOVA coupled with Bonferroni post-tests in a, b, n = 7, *P < 0.05, **P < 0.01 vs. control; †P < 0.05 vs. baseline (second day prior to stress); #P < 0.05, ##P < 0.01 vs. SIH

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