Fig. 2 | Hypertension Research

Fig. 2

From: Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation

Fig. 2

The effects of intracerebroventricular injection of clodronate on the brain PVM expression, plasma IL-1β levels, and blood pressure in WKY and SHRSP. a The number of brain PVMs evaluated by immunostaining. Clodronate significantly decreased brain PVMs in both WKY and SHRSP. b Plasma IL-1β levels. c Time-course of mean blood pressure after clodronate or vehicle administration. d Δmean blood pressure from before to 2 weeks after clodronate or vehicle administration. WKY-vehicle, n = 5; WKY-CLOD, n = 5; SHRSP-vehicle, n = 7; SHRSP-CLOD, n = 7. *p < 0.05 as indicated; †p < 0.05, SHRSP-vehicle vs. WKY-vehicle; #p < 0.05, SHRSP-CLOD vs. SHRSP-vehicle. CLOD clodronate

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