Fig. 3 | Hypertension Research

Fig. 3

From: Activation of arginase II by asymmetric dimethylarginine and homocysteine in hypertensive rats induced by hypoxia: a new model of nitric oxide synthesis regulation in hypertensive processes?

Fig. 3

Endothelial NOS synthase activity and expression. A Measurement of eNOS activity was performed in a homogenate of the aortic arteries of rats exposed to hypoxia by measuring L-[3H]-citrulline. NOS synthase activity in hypoxia-induced hypertensive rats was significantly lower after exposure to hypoxia (n = 10 *p < 0.001) and significantly higher than that in nonhypertensive rats (n = 10, **p < 0.001 nonhypertensive rats vs. hypoxia-induced hypertension rats). B Effect of hypoxia exposure on eNOS mRNA expression in hypoxia-induced hypertensive and nonhypertensive rats; levels before exposure to hypoxia (white bar) and after 30 days of exposure (black bar) (n = 6 per group, *p < 0.001 and **p < 0.01) in homogenized aortic arteries are shown. The boxes correspond to the Western blot analysis from aortic artery homogenates

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