Fig. 6

Crocin activates the placental Nrf-2/HO-1 pathway in L-NAME-induced preeclampsia rats with gestational hypertension. A, B The contents of total Nrf-2, nuclear Nrf-2, and HO-1 were determined by the western blot analysis on GD 20. C, D Placental levels of Nrf-2 and HO-1 were measured by ELISA on GD 20. Values are the mean ± SD (n = 12 in each group). *p < 0.05 compared to the control; #p < 0.05, ##p < 0.01 compared to L-NAME