Table 2 Characteristics of blood pressure and MRI findings

From: Home-measured orthostatic hypotension associated with cerebral small vessel disease in a community-based older population

 

No-HOH Episode group (n = 352)

1 HOH Episode group (n = 214)

≥2 HOH Episodes group (n = 97)

P value

Characteristic of blood pressure

 Clinic SBP (mm Hg)

148.98 ± 15.96

150.96 ± 16.33

152.31 ± 16.67

0.130

 Clinic DBP (mm Hg)

77.48 ± 8.79

76.21 ± 9.54

78.29 ± 10.81

0.133

 Home supine SBP (mm Hg)

138.01 ± 15.90

140.22 ± 15.85

141.70 ± 15.98

0.074

 Home supine DBP (mm Hg)

73.16 ± 9.05

72.07 ± 9.70

74.02 ± 10.87

0.201

 Home orthostatic SBP (mm Hg)

126.03 ± 17.34

123.58 ± 17.16

117.07 ± 17.79*,†

<0.001

 Home orthostatic DBP (mm Hg)

67.70 ± 9.42

64.00 ± 9.84*

64.77 ± 11.23*

<0.001

 Changes in home supine-to-orthostatic SBP (mm Hg)

11.99 ± 6.41

16.64 ± 6.59*

24.63 ± 5.13*,†

<0.001

 Changes in home supine-to-orthostatic DBP (mm Hg)

5.47 ± 3.10

8.07 ± 1.39*

9.25 ± 1.63*,†

<0.001

Brain magnetic resonance imaging

 WMH volume (mL)

2.23 (1.65, 3.07)

3.05 (2.52, 3.96)*

3.84 (3.05, 5.06)*,†

<0.001

 WMH-to-TIV ratio (%)

0.18 (0.13, 0.24)

0.24 (0.19, 0.29)*

0.28 (0.23, 0.36)*,†

<0.001

 Prevalence of Fazekas scale ≥ 2 [n (%)]

33 (9.4)

40 (18.7)*

33 (34.0)*,†

<0.001

 Prevalence of lacunes [n (%)]

31 (8.8)

33 (15.4)*

33 (34.0)*,†

<0.001

 Number of lacunes [total counts (%)]

92 (26.1)

84 (39.3)*

136 (140.2)*,†

<0.001

 Prevalence of EVRS (n [%])

32 (9.1)

37 (17.3)*

27 (27.8)*,†

<0.001

 Number of EVRS [total counts (%)]

146 (41.5)

147 (68.7)*

134 (138.1)*,†

<0.001

 Prevalence of microbleeds [n (%)]

25 (7.1)

23 (10.7)

15 (15.5)*

0.034

 Number of microbleeds [total counts (%)]

75 (21.3)

67 (31.3)

49 (50.5)*

0.031

  1. Data are expressed as the mean ± standard deviation, median with interquartile range, numbers with percentages, or total counts
  2. HOH home-measured orthostatic hypotension, SBP systolic blood pressure, DBP diastolic blood pressure, WMH white matter hyperintensities, TIV total intracranial volume, EVRS enlarged Virchow–Robin spaces
  3. *P < 0.05, as compared with 1 HOH Episode group
  4. †P < 0.05, as compared with ≥2 HOH Episodes group
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