Fig. 5
From: Angiotensin II blockers improve cardiac coronary flow under hemodynamic pressure overload

A In mice after aortic banding for 4 weeks, there were significant changes changes in pressure-sensitive protein expression of connective tissue growth factor (CTGF), signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1α (HIF-1α) compared with sham mice. B Conversely, in mice after angiotensin II treatment for 4 weeks, the expression of the above pressure-sensitive proteins was significantly increased compared with that in sham mice (n = 10–12 for each group)