Table 2 Multivariable logistic regression analyses for the risk of hypertension

From: Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication

 

Model 1

Model 2

Model 3

Model 4

 

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

XOR activity (per 10 pmol/h/mL plasma)

1.093 (1.030–1.173)

0.003

1.069 (1.005–1.148)

0.034

1.080 (1.015–1.161)

0.015

1.091 (1.023–1.177)

0.007

Sex (male)

0.960 (0.520–1.769)

0.897

0.921 (0.479–1.170)

0.804

0.990 (0.513–1.912)

0.977

0.950 (0.451–2.004)

0.894

 Interaction*

 

0.906

 

0.860

 

0.828

 

0.812

Age (per 1 year)

1.074 (1.050–1.102)

<0.001

1.065 (1.035–1.097)

<0.001

1.056 (1.027–1.088)

<0.001

1.046 (1.014–1.081)

0.004

eGFR (per 1 mL/min/1.73 m2)

–

–

0.990 (0.963–1.016)

0.453

0.988 (0.959–1.016)

0.411

0.980 (0.949–1.010)

0.185

BNP (per 1 pg/mL)

–

–

1.018 (1.005–1.035)

0.006

1.013 (1.001–1.031)

0.040

1.014 (1.000–1.032)

0.049

Body mass index (per 1)

–

–

1.149 (1.053–1.261)

0.002

–

–

–

–

HOMA-IR (per 1)

–

–

–

–

1.128 (1.020–1.252)

0.020

1.094 (0.979–1.222)

0.111

Current smoking habit

–

–

–

–

–

–

0.886 (0.367–2.140)

0.787

Alcohol consumption habit

–

–

–

–

–

–

0.745 (0.357–1.554)

0.431

 

AIC: 274

AIC: 263

AIC: 257

AIC: 237

  1. Interaction*: Sex-plasma XOR activity
  2. AIC Akaike’s information criterion, BNP brain natriuretic peptide, CI Confidence Interval, eGFR estimated glomerular filtration rate, HOMA-IR homeostasis model assessment of insulin resistance, OR odds ratio, XOR xanthine oxidoreductase
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