Table 2 Results from subgroup analyses of the net change in SBP and DBP

From: The effect of digital therapeutics intervention on improving hypertension management in adults: a meta-analysis of randomized controlled trial

Subgroup Analysis

SBP

DBP

No. of Studies

Net Change, mmHg

95% Cl

heterogeneity

P

No. of Studies

Net Change, mmHg

95% Cl

heterogeneity

P

I2, %

P Value

I2, %

P Value

Duration of intervention

 ≥6 months

8

−3.97

−6.38 to −1.57

82

<0.00001

0.81

7

−1.39

−2.53 to −0.26

55

0.04

0.23

 <6 months

5

−3.4

−7.41 to 0.60

86

<0.00001

3

−2.61

−4.28 to −0.95

53

0.12

Intervention scenario setting

 hospital

4

−2.59

−4.97 to −0.21

57

0.07

0.37

8

−1.66

−2.88 to −0.43

67

0.004

0.45

 primary care clinics

9

−4.28

−7.06 to −1.50

85

<0.00001

2

−2.45

−4.09 to −0.81

21

0.26

Average age

 ≥60 years

4

−5.59

−8.66 to −2.52

79

0.003

0.17

3

−2.15

−4.17 to −0.14

84

0.002

0.62

 <60years

9

−2.67

−5.41 to 0.07

85

<0.00001

7

−1.55

−2.83 to −0.26

47

0.08

Total follow-up

 ≥200

7

−4.49

−6.93 to −2.06

88

<0.00001

0.34

5

−1.38

−2.26 to −0.51

43

0.14

0.40

 <200

6

−2.38

−5.95 to 1.19

67

0.01

5

−2.43

−4.70 to −0.16

61

0.04

Take antihypertensive drugs at baseline

 Yes

6

−4.56

−7.95 to −1.18

90

<0.00001

0.35

3

−1.9

−3.62 to −0.17

85

0.001

0.88

 No

7

−2.75

−4.48 to −1.02

37

0.14

7

−1.72

−3.11 to −0.33

43

0.11

Uncontrolled blood pressure at baseline

 Yes

7

−4.4

−7.26 to −1.53

82

<0.00001

0.51

5

−1.06

−2.06 to −0.06

31

0.21

0.09

 No

6

−2.98

−6.09 to 0.13

83

<0.00001

5

−2.47

−3.73 to −1.21

49

0.1