Table 2 Transcriptome analysis – normalised RNA expression (RPKM = reads per kilobase of transcript per million) of various ion channels that might serve as putative baroreceptors in the adventitia of the fresh frozen aortic arch tissue samples
From: Identification of putative baroreceptors in human aortic arch by histological and omics analyses
Gene ID | Gene name | AoA area | AoA 1/analysed segments | AoA 3/analysed segments | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1/1 | 1/3 | 1/5 | 1/7 | 3/1 | 3/3 | 3/5 | 3/9 | Mean ± SDa | P-value | |||
ENSG00000072182 | ASIC4 | Upper | 20.7 | 2.2 | 1.7 | 2.3 | 4.0 | 12.3 | 2.8 | 8.2 | 6.8 ± 6.7 | 0.674 |
Lower | 4.5 | 5.4 | 4.0 | – | 5.7 | 10.6 | 1.8 | 7.2 | 5.6 ± 2.8 | |||
ENSG00000162572 | SCNN1D | Upper | 20.6 | 9.9 | 2.5 | 7.2 | 10.3 | 24.2 | 8.2 | 15.4 | 12.3 ± 7.3 | 0.539 |
Lower | 24.1 | 23.0 | 8.7 | 14.6 | 13.4 | 8.4 | 6.5 | 17.1 | 14.5 ± 6.6 | |||
ENSG00000104321 | TRPA1 | Upper | 17.8 | 2.3 | 1.9 | 4.2 | 8.1 | 8.6 | 8.7 | 6.7 | 7.3 ± 5.1 | 0.906 |
Lower | 9.5 | 7.5 | 0.9 | 5.7 | 6.8 | 13.2 | 8.9 | 7.9 | 7.6 ± 3.5 | |||
ENSG00000144935 | TRPC1 | Upper | 4.9 | 3.6 | 5.1 | 5.5 | 8 | 6.7 | 13.5 | 5 | 6.5 ± 3.1 | 0.084 |
Lower | 3.7 | 1.8 | 2.7 | 1.7 | 6.6 | 6.8 | 5.9 | 3.4 | 4.1 ± 2.1 | |||
ENSG00000118762 | TRPP2 | Upper | 40.0 | 51.2 | 68.8 | 64.6 | 268 | 244 | 188 | 81.1 | 126 ± 93 | 0.830 |
Lower | 52.2 | 57.2 | 57.9 | 33.5 | 262 | 209 | 182 | 73 | 115 ± 88 | |||
ENSG00000138741 | TRPC3 | Upper | 8.5 | 2.6 | 1.2 | – | 2.3 | 1.4 | 4.6 | 4.1 | 3.5 ± 2.5 | 0.969 |
Lower | 3.0 | 2.2 | 1.8 | – | 5.9 | 3.9 | 4.2 | 3.4 | 3.4 ± 1.4 | |||
ENSG00000069018 | TRPC7 | Upper | 20.6 | 0.5 | 2.3 | 1.5 | 0.6 | 3.9 | 6 | 5.3 | 5.1 ± 6.6 | 0.929 |
Lower | 2.2 | – | 1.3 | – | 7.8 | 8 | 5.3 | 4.5 | 4.9 ± 2.8 | |||
ENSG00000083067 | TRPM3 | Upper | 33.6 | 5.2 | 2.4 | 2.8 | 11.2 | 5.4 | 17 | 9.3 | 10.9 ± 9.7 | 0.969 |
Lower | 8.3 | 5.1 | 7.0 | 7.5 | 12.7 | 18 | 11 | 16 | 10.7 ± 4.6 | |||
ENSG00000119121 | TRPM6 | Upper | 15.0 | 1.9 | 1.8 | 2.0 | 5.8 | 4.5 | 8.8 | 4.8 | 5.6 ± 4.5 | 0.896 |
Lower | 4.0 | 2.8 | 1.8 | 5.4 | 5.7 | 15.1 | 4.8 | 7.3 | 5.9 ± 4.1 | |||
ENSG00000144481 | TRPM8 | Upper | 38.6 | 5.5 | 2.4 | 2.1 | 8.9 | 17.2 | 7.8 | 12.5 | 11.9 ± 9.4 | 0.897 |
Lower | 6.4 | 13.7 | 2.8 | 11.6 | 10.2 | 17.5 | 12.8 | 15.2 | 11.3 ± 4.8 | |||
ENSG00000127412 | TRPV5 | Upper | 11.5 | – | – | – | 0.6 | – | 2.1 | 0.7 | 3.7 ± 5.2 | 0.289 |
Lower | 1.1 | – | 0.7 | 2.1 | 1.6 | 2.4 | 0.9 | 2.1 | 1.6 ± 0.7 | |||
ENSG00000165125 | TRPV6 | Upper | 21.4 | 2.1 | 2.0 | 0.7 | 9.5 | 9.9 | 12 | 8.6 | 8.3 ± 6.8 | 0.918 |
Lower | 6.6 | 4.2 | 5.2 | 2.0 | 7 | 17.2 | 10.6 | 16 | 8.6 ± 5.5 | |||
ENSG00000055732 | MCOLN3 | Upper | 8.7 | 1.5 | 2.3 | 0.4 | 3.2 | – | 1.9 | 5.1 | 3.3 ± 2.8 | 0.785 |
Lower | 1.0 | 4.0 | 0.6 | – | 4.5 | 3.3 | 2.5 | 4.8 | 3.0 ± 1.7 | |||
