Fig. 5: Late-stage modification of natural products and medicinally relevant molecules. | Nature Communications

Fig. 5: Late-stage modification of natural products and medicinally relevant molecules.

From: Nickel-catalyzed deaminative Sonogashira coupling of alkylpyridinium salts enabled by NN2 pincer ligand

Fig. 5

Reaction conditions: pyridinium salt (0.3 mmol), alkyne (0.45 mmol), NiCl2·6H2O (10 mol%), L4 (10 mol%), K3PO4 (1.3 equiv), THF (1.5 mL), 80 oC. Isolated yields. For 7, 9, 15, 16, 17, 18, 19 and 20, reactions were conducted in DMF (1.5 mL).

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