Addendum to: Nature Communications https://doi.org/10.1038/s41467-022-35595-6, published online 23 December 2022
We would like to make readers aware that after the publication of the original article, we found that the parameters for PhyloCSF score calculation were obtained for an alignment other than 120 mammals. This made our analysis less sensitive than intended. Recalculation of the PhyloCSF score with the intended parameters produced a larger dataset of 177 genes that contains 58 of 60 genes in the original dataset are provided in Supplementary Data 1 here. This difference does not alter the main conclusion of the article regarding the substantial prevalence of ribo-seq-supported non-AUG-initiated N-terminal extensions over those supported by phylogenetic analysis. However, it indicates that the number of N-terminally extended proteoforms satisfying our criteria for protein-coding evolution is three times greater than originally reported. The corrected parameters for 120 mammals are now available on the PhyloCSF github page (https://github.com/mlin/PhyloCSF/tree/master/PhyloCSF_Parameters).
Author information
Authors and Affiliations
Corresponding authors
Supplementary information
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Fedorova, A.D., Kiniry, S.J., Andreev, D.E. et al. Addendum: Thousands of human non-AUG extended proteoforms lack evidence of evolutionary selection among mammals. Nat Commun 15, 228 (2024). https://doi.org/10.1038/s41467-023-44405-6
Published:
DOI: https://doi.org/10.1038/s41467-023-44405-6
This article is cited by
-
Deep learning to decode sites of RNA translation in normal and cancerous tissues
Nature Communications (2025)
