Fig. 1: Improved rod and cone functions in Prph2Y141C/+ and Prph2K153∆/+ mice following partial ablation of Rho. | Nature Communications

Fig. 1: Improved rod and cone functions in Prph2Y141C/+ and Prph2K153∆/+ mice following partial ablation of Rho.

From: Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders

Fig. 1

Representative scotopic (A) and photopic (B) ERG waveforms at P30 from all genotypes. C–F Mean maximum amplitudes of scotopic a-waves and b-waves, as well as photopic b-waves, plotted as mean ± SD at P17, P30, and P90. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001 by one-way ANOVA with Tukey’s post-hoc comparison (see Table S3 for corresponding p values). N = 9-15 animals/genotype/age. *denotes comparisons between (C, D) Prph2Y141C/+ and Prph2Y141C/+/Rho+/- or (E, F) Prph2K153∆/+ and Prph2K153∆/+/Rho+/-.

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