Fig. 2: Partial ablation of RHO does not affect ONL thickness in Prph2K153∆/+ or Prph2Y141C/+. | Nature Communications

Fig. 2: Partial ablation of RHO does not affect ONL thickness in Prph2K153∆/+ or Prph2Y141C/+.

From: Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders

Fig. 2

A Representative images of H&E stained retinal sections at P30 and P90. B, C Nuclei counts were performed in 100 µm width windows in retinal sections taken from the indicated genotypes. Images were captured every 500 µm starting at the optic nerve head sections, and nuclei counts from multiple regions were plotted as mean ± SD for the listed genotypes (n = 3 for each genotype). ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 by two-way ANOVA (P30 Prph2Y141C/+: Interaction P = 0.8626, Row Factor P < 0.0001, and Column Factor P < 0.0001. P90 Prph2Y141C/+: Interaction P = 0.0001, Row Factor P < 0.0001, and Column Factor P < 0.0001. P30 Prph2K153∆/+: Interaction P = 0.0026, Row Factor P < 0.0001, and Column Factor P < 0.0001. P90 Prph2K153∆/+: Interaction P < 0.0001, Row Factor P < 0.0001, and Column Factor P < 0.0001.) with Tukey’s post-hoc comparison. *denotes comparisons between (B) Prph2Y141C/+ or (C) Prph2K153∆/+and (B) Prph2Y141C/+/Rho+/- or (C) Prph2K153∆/+/Rho+/-. Scale bar corresponds to 100 µm.

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